The Treatment of Lymphogranuloma Venereum and Granuloma Inguinale in Humans With Aureomycin

Abstract

a preliminary study which is in prcss,' IVC have reported results in Cmenty-five cases of lymphogranuloma venercum treated with Anreomycin. This study was conducted between January 22nd, 1948, and April 24th, 1948. The results obtained with this new therapeutic agent were so superior to all other forms of therapy2 that had been used by us that me did not hesitate to continue its use. In the earlier paper, it was stated that Aureomycin was used for the first time in human beings. Apparently we were dealing with an antibiotic that could cure this virus infection in humans.The present paper confirms our previous observations. It is a report of ten additional cases of lymphogranuloma venereum, treated with -1ureomycin since our original article was sent in for publication. It also includes a follow-up report on fourteen of our original twenty-five cases, and a preliminary report on the use of Aureomycin in three cases of granuloma inwinale. Lymphogranuloma Venereum'Lo date, the total number of patients to whom we have administered Aureomycin, as the sole form of specific therapy, is thirty-five, and it should be stated that thcy were all hospitalized. This was done so that we could bc sure that the patients received an adequate amount, of the drug under controlled cnnditions and, also. so that n e could properly evaluatr the results. J l o s t patients receivcd 1 0 to 40 ing. of Aureomycin daily, by intramiiscwlar injection. The drug n as dissolved in 2 cc. of normal saline soliition. In our previous series, a mild, hypochromic anemia developed when ne used a special diluent. In all cases, the anemia was corrected by the administration of folic acid and iron (Folvron), In some of our earlier c a m , n e used folic acid and iron as an anemia preventive, while in this group we found this precaution unnecessary.Because of a pre-existing anemia, two patients in this series received folic acid and iron v hile being treated with Aurcomycin. We feel that the we are gratrful to the late Dr. k. RiibbaRoa and his associates at t h e Lederle Lalmratoricq Division 4merican C yanaruid Company. for their cooperation and for the Aureomyriii uwd. 1318 1

Granuloma Inguinale in Scotland

“…Streptomycin, terramycin, chloramphenicol, and aureomycin have all proved useful in actual practice, the dosage varying according to the duration of infection and the chronicity of the disease. Important observations regarding the potency of aureomycin are to be found in the work of Wright et al (1948), Hill et al (1949), and Wammock et al (1950. Further, Greenblatt et al (1950) reported good results using aureomycin by mouth in a series of 46 patients, five of whom had not responded to streptomycin.…”

Chemotherapy of Virus and Rickettsial Infections

“…Neither aureomycin nor chloramphenicol is significantly virucidal in vitro. There is some evidence for the clinical effectiveness of aureomycin against psittacosis (95) and considerable data (96,97) which indicate a curative effect on acute lymphogranuloma venereum. Other antibiotics tested against Chlamydozoaceae and found to be inac tive include streptomycin as previously mentioned (75,76) bacitracin (73), and streptothricin (75).…”

The Clinical Evaluation of Aureomycin 123

“…Successful clinical trials have been reported in a wide variety of bacterial and rickettsial infections, as well as infections due to lymphopathia venereum virus and the causative agent of primary atypical pneumonia (4,6,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Toxic reactions have been few and insignificant.…”