The Treatment of Ocular Toxoplasmosis with Spiramycin

Activity of spiramycin against Toxoplasma gondii in vitro, in experimental infections and in human infection

“…Chodos & Habegger-Chodos (1961) showed that in a series of 67 patients spiramycin was an effective agent for use in posterior uveitis presumably caused by toxoplasma. Fajardo, Furguiele & Leopold (1962) reported a series of 87 patients who had received either spiramycin and steroids, sulphadiazine and pyrimethamine and steroids or steroids therapy alone.…”

Toxoplasmosis and Spiramycin

“…A broadspectric antibiotic spiramycin which was found in 1954 has a marked effect on the toxoplasmosis at least in animal experiments (Bogacr 1954, Gariit & Eyles 1958 and Bonaduce 1960). On the basis of this Chodos & Habegger- Chodos (1961) experimented with this drug also in human toxoplasmosis with good results -90 per cent of 67 cases were cured. Their conclusion was: nspiramycin administered in a singly dose of 2 g is the therapy of choice in ocular toxoplasmosis.<c…”

Review of Pediatric Uveitis

“…Long-term treatment with trimethoprim-sulfamethoxazole may prevent recurrences [74]. In pregnant women with newly acquired toxoplasmosis, treatment with spiramycin [75] or azithromycin [76,77] may be used to prevent congenital infection. This is done in concert with the obstetrician, infectious disease specialist and neonatologist, and should be continued until the infant is 1 year of age [78].…”