The Treatment of Recurrent Unresectable and Malignant Meningiomas with Interferon Alpha-2B

Abstract

These results suggest that IFN-alpha is effective in the treatment of recurrent malignant meningiomas.

Radiological response in an incidental meningioma in a patient treated with chemotherapy combined with CP-751,871, an IGF-1R inhibitor

“…They are one of the most common intracranial tumours. While benign, some may need treatment due to symptomatic compression of adjacent structures, when the treatment of choice is surgery or radiotherapy [1]. The treatment of recurrent or unresectable meningiomas is diffi cult.…”

Reverse Seeding of Recurrent Intraspinal Malignant Meningioma

“…Chemotherapy has little benefit, even in histologically atypical or malignant meningiomas [10]. Chemotherapeutic regimens (including cytosine arabinoside, Adriamycin, and vincristine; dacarbazine, Adriamycin, and high-dose ifosfamide; cyclophosphosphamide, Adriamycin, vincristine, interferon-α-2B and hydroxyurea, and hydroxyurea) were administered to patients, with a limited number of patients showing only marginal efficacy [1, 3, 10, 16, 17, 18]. …”

“…Intracranial meningiomas account for approximately 20% of all intracranial neoplasms [3]and 25–46% of primary spinal tumors [4]. Ten to 15% of all meningiomas are considered malignant [1, 2].…”

Rhabdoid meningioma in a child: Report of a case and literatures review

“…Complications include a rate of radiation necrosis requiring further surgical resection of 13% in one series. Immunotherapy with interferon alpha, hyroxyurea and antiprostaglandins such as Mifepristone have been administered in unresectable tumors [23,24] . None have shown efficacy in treating atypical/ anaplastic meningiomas.…”