The Treatment of Renal Cell Carcinoma with Solitary Metastasis

O'Dea, Michael J.; Zincke, Horst; Utz, David C.; Bernatz, Philip E.

doi:10.1016/s0022-5347(17)57264-x

Cited by 279 publications

(96 citation statements)

References 9 publications

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“…In selected patients, surgical metastasectomy has become an accepted treatment and is reported to prolong survival in many cancers (1,2). Although complete resections are thought to occur in the majority of patients, relapse rates can be as high as 70% to 80% and recurrence in the lung can be as high as 30% to 40% (3), indicating that small foci of metastatic disease may elude resection.…”

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confidence: 99%

Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/neu

Koyama

Hama

Urano

et al. 2007

Clinical Cancer Research

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Purpose: Surgical resection of pulmonary metastases is now a clinically accepted cancer therapy but its success depends on the accurate localization and removal of all tumor foci. To enhance the detection of pulmonary metastases during surgery, we developed an i.v. administered optical probe that uses a monoclonal antibody, Herceptin (trastuzumab), conjugated to a fluorophore, rhodamine green (RhodG), to specifically detect human epidermal growth factor receptor type 2 (HER2/neu)^expressing pulmonary lesions in an animal model of lung metastases. Experimental Design: Pulmonary metastases were induced by i.v. injection of gene-transfected murine embryonic fibroblasts (3T3) cells in a murine model to produce a mixed population of HER2+ and HER2À tumors. To image these tumors, an anti-HER2 (Herceptin) or a control (HUT) complementarity-determining region^grafted antibody was conjugated to RhodG and injected i.v. into mice. Spectral fluorescence imaging was done after thoracotomy and images were correlated with gross and microscopic pathology to assess sensitivity and specificity. Results: HER2+ tumors injected with Herceptin-RhodG were more fluorescent than either HER2À tumors or HER2+ tumors injected with HUT-RhodG at all time points. The maximal fluorescence signal in HER2+ tumors injected with Herceptin-RhodG was observed at 1day postinjection. The tumors fluoresced primarily at the rim and not their center, reflecting the binding-site barrier that is commonly seen with high-affinity antibodies. Conclusion: A HER2-targeted optical imaging probe shows the ability to specifically enhance HER2+ pulmonary metastases but not HER2À pulmonary metastases. The high sensitivity and specificity of this probe is encouraging for the development of antigen-targeted optical probes to assist in the resection of pulmonary metastases.

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confidence: 99%

Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/neu

Koyama

Hama

Urano

et al. 2007

Clinical Cancer Research

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“…With regard to RCC, metastatic tumors are sometimes revealed more than 5 years after the initial excision (19,20). Venu et al (9) and Robertson and Gertler (7) reported a metastatic ampullary tumor from RCC1 1 years and 12 years after nephrectomy, respectively; Letessier et al (1 1) reported CBD metastasis 1 4 years after nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the slow growing nature of the RCC,we did not discover the RCCin the early stage, so eventually obstructive jaundice, which was the metastatic form was the first sign of the RCC. As far as the treatment is concerned, O'dea et al (20) demonstrated that surgical resection of the metastatic lesion seem to offer the best results in patients whopresented a solitary metastatic lesion after nephrectomy, however, the prognosis was uniformly poor. Kauffmann et al (10) treated the intracholedocal metastatic tumor of RCCby intraluminal irradiation with radioiridium in order to maintain the patency of the CBDby controlling tumor proliferation within the duct, which resulted in a favorable outcome for 18 months.…”

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confidence: 99%

Intraluminal Tumor of the Common Bile Duct as a Metastasis of Renal Cell Carcinoma.

et al. 1996

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A 57-year-old womanwas admitted for evaluation of liver dysfunction. A physical examination revealed jaundice and a left abdominal mass, which was diagnosed as being a large renal tumor. Cholangiography showed a smooth filling defect 1 cm in diameter at the commonbile duct. Left nephrectomy, and resection of the commonbile duct were performed. The pathological diagnosis was metastasis of the commonbile duct wall resulting from renal cell carcinoma. Metastatic commonbile duct tumors are extremely rare. However, it is important to consider that this is one of the causes of obstructive jaundice. (Internal Medicine 35: 720-723, 1996)

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“…encuentran una supervivencia a los 2 años del 78% cuando se identifican metástasis en la cavidad oral y una supervivencia a los 5 años del 50% cuando el desarrollo de metástasis tiene lugar tras la nefrectomía. 8 …”

Section: Described a Rate Of 02% Of All Malignant Lingual Lesions Punclassified

“…O'Dea et al reported a survival rate at two years of 78% when metastasis to the oral cavity is identified, and a survival at 5 years of 50% when metastasis develops after a nephrectomy. 8 …”

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Metástasis lingual de carcinoma renal

Regalado

Álvarez

Martínez

et al. 2007

Rev Esp Cirug Oral y Maxilofac

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Paciente varón de 81 años de edad con antecedentes personales de hipotiroidismo, hipertrofia benigna de próstata, glaucoma y nefrectomía derecha por carcinoma renal de células claras en Junio de 2004 (Fig. 1). Actualmente presenta metástasis pulmonares bilaterales en seguimiento por el Servicio de Oncología quien, hasta la fecha, no ha considerado indicado el inicio de tratamiento quimioterápico.Acude a consultas externas de Cirugía Oral y Maxilofacial por presentar tumoración en borde lateral lingual de varias semanas de evolución. A la exploración física distinguimos una tumoración excrecente polilobulada y friable en borde posterolateral derecho de la lengua y dimensiones de 2x1 cm (Fig. 2). El resto de la exploración es normal, no palpándose adenopatías cervicales clínicamente positivas.Ante estos hallazgos tomamos una muestra para biopsia. El estudio anátomopatológico objetiva metástasis ulcerada de carcinoma de células claras y, dados los antecedentes clínicos del paciente, se diagnostica como metástasis del carcinoma renal.Como estrategia terapéutica a seguir consideramos la extirpación local de la lesión ya que el estado general del paciente era bueno y presentaba molestias en la zona.Mediante anestesia local se procede a su extirpación y cierre directo. La pieza quirúrgica obtenida fue descrita macroscópicamente como formación polilobulada irregular de 1,9x1,1 cm de dimensiones máxi-mas, con coloración pardusca y áreas negruzcas al corte. Su estudio histológico definitivo confirmó la metástasis ulcerada de carcinoma de células claras de riñón (Fig. 3).La evolución del paciente ha sido, hasta el momento, favorable.

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The Treatment of Renal Cell Carcinoma with Solitary Metastasis

Cited by 279 publications

References 9 publications

Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/neu

Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/neu

Intraluminal Tumor of the Common Bile Duct as a Metastasis of Renal Cell Carcinoma.

Metástasis lingual de carcinoma renal

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