The trend of leprosy epidemiological indicators in the elderly population from the ceará state (2002 to 2014)

Farias, Karliana Nascimento; Nogueira, Paula Sacha Frota; Sales, Joana Maria Rocha; Silva, Maria Josefina da; Marques, Marília Braga

doi:10.9789/2175-5361.rpcfo.v12.7185

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The main findings from the studies indicated that the relapse occurrence time after the initial PCT treatment is equal to or greater than 5 years after clinical cure, with higher prevalence of patients treated for MB 26,27,28,29 . Complementary findings from the cohort studies revealed that relapse cases were more prevalent among cases with positive bacilloscopy when compared to those with negative bacilloscopy in the initial treatment 13,14,15,30,31,32,33,34,35,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] .…”

Section: Characteristics Of the Population And Clinical Aspects Accor...mentioning

confidence: 99%

Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Verônica da Silva,

Santos de Sousa,

Ferreira

et al. 2023

Preprint

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Objective: To synthesize the best scientific evidence related to estimating the prevalence of leprosy relapse cases after polychemotherapy treatment.Method:A systematic review was conducted following the JBI methodology for systematic reviews of prevalence studies, and the reporting stage adhered to PRISMA-P, with registration No.: CRD42020177141. The inclusion criteria were adopted following the PopCoCo mnemonic (Population, Condition, Context). Population: people of both genders and any age, diagnosed with leprosy relapse, and treated with paucibacillary or multibacillary therapeutic regimes. Condition: leprosy relapse after Polychemotherapy (PCT) estimated as a proportion of cases.Context: studies conducted within the scope of health services. Databases used: Medline, LILACS, Embase, CINAHL, Scopus, WoS, CARPHA; Mendeley reference manager. A random-effects meta-analysis model was applied, and heterogeneity was assessed using the Higgins test.Results: Out of 41 studies included in the review, involving a total of 93,461 patients with leprosy, 4.09% (n=3,830) were eligible for relapse after polychemotherapy. Of them, 69.71% (n=2,670) were treated both with multibacillary and with paucibacillary regimes (72.36%, n=1,932; and 27.64%, n=738, respectively), and with a bacilloscopy index ≥4. Relapse prevalence was observed in males and in people aged over 30 years old. The meta-analysis estimated the global prevalence of leprosy relapse at 11% (95%CI: 0.09-0.12), with higher prevalence rates in Brazil (31%) and India (13%).Conclusion: There is evidence of high global prevalence of leprosy relapse after PCT, with higher estimates in India and Brazil, countries burdened with higher prevalence of the disease.SYNTHESISAlthough leprosy us an ancient disease with a scientifically proven effective treatment, it remains a Public Health problem. This is not only due to the disease high prevalence but also to its potential to cause physical disabilities, leading to emotional and social impacts and, consequently, compromising quality of life. In addition to the new cases of the disease, another concern commonly reported in the literature is leprosy relapse after polychemotherapy, as it has repercussions on therapeutic effectiveness. The relapse causes are usually associated with therapeutic failure due to incomplete treatment, misclassification in the initial treatment, and multidrug resistance. This study provides insights to verify the disease current prevalence based on scientific evidence, which can contribute to expanding the prevention strategies.

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Section: Characteristics Of the Population And Clinical Aspects Accor...mentioning

confidence: 99%

Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Verônica da Silva,

Santos de Sousa,

Ferreira

et al. 2023

Preprint

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Perfil Epidemiológico Da Hanseníase Em Idosos Através Dos Sistemas De Informações Em Saúde Datasus

Veras,

Mendes,

Branco

2024

Rev. Contemp.

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A hanseníase é uma doença crônica e infectocontagiosa causada pelo Mycobacterium leprae, com predileção pela pele e nervos periféricos. No Brasil, representa um desafio de saúde pública. A pesquisa justifica-se em investigar o perfil epidemiológico da hanseníase em idosos, devido à sua natureza crônica e incapacitante, com complicações graves se não tratadas precocemente. O objetivo deste estudo é identificar e analisar o perfil epidemiológico dos casos de hanseníase diagnosticados em idosos no Brasil, durante uma década. A metodologia consistiu em um estudo epidemiológico descritivo de corte transversal dos casos novos de hanseníase em residentes no Brasil, com dados obtidos no DATASUS, SINAN, no período de 2013-2023, por faixas etárias. Os dados do DATASUS indicam uma prevalência da doença em idosos com baixa escolaridade, principalmente na região Nordeste. A doença é mais comum em homens entre 60 e 69 anos de idade, sendo mais frequente em indivíduos de origem parda ou branca. A forma clínica mais comum da doença foi a Dimorfa, com predominância de formas multibacilares nessa faixa etária. Apesar da maioria dos casos serem de grau zero de incapacidade, a presença de casos com graus I e II ressalta a importância de um acompanhamento cuidadoso. Dessa forma, o estudo contribui significativamente para compreensão da hanseníase em idosos e ressalta a importância da vigilância epidemiológica e medidas preventivas e terapêuticas.

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The trend of leprosy epidemiological indicators in the elderly population from the ceará state (2002 to 2014)

Cited by 2 publications

References 33 publications

Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Leprosy Relapse After Polychemotherapy: A Systematic Review and Meta-Analysis

Perfil Epidemiológico Da Hanseníase Em Idosos Através Dos Sistemas De Informações Em Saúde Datasus

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