The triglyceride-glucose index as a novel marker associated with sarcopenia in non-diabetic patients on maintenance hemodialysis

Chen, Ruoxin; Zhang, Liuping; Zhang, Mengyan; Wang, Ying; Liú, Dan; Li, Zuo‐Lin; Zhang, Xiaoliang; Jin, Hui; Liu, Bi‐Cheng; Liu, Hong

doi:10.1080/0886022x.2022.2128373

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…Ahn et al reported that higher TyG index values were found to be associated with an increased risk of low skeletal muscle mass index in Korean adults [ 20 ]. Other studies also showed that elevated levels of TyG index are a risk factor for reduced muscle mass or strength [ 21 , 22 ], even in adolescents between the ages of 12 and 18 [ 36 ]. In addition to evidence from cross-sectional studies, post hoc analyses of a prospective study suggested that baseline lower handgrip strength levels were inversely associated with the three-year follow-up TyG index values, which indicate that handgrip strength can be a predictor of future insulin resistance [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Yuan,

Chen,

Lin

et al. 2023

Cardiovasc Diabetol

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Background Frailty is an age-related geriatric syndrome that leads to a series of clinically negative events. A better understanding of the factors associated with frailty assists in preventing its progression. The triglyceride-glucose (TyG) index, a simple alternative index of insulin resistance, has not yet been proven to be associated with frailty. The present study aimed to investigate the association between the TyG index and its trajectory with frailty from a cross-sectional, retrospective and prospective level based on an ongoing cohort. Methods This longitudinal study included 1,866 older residents from the “Fujian prospective aging cohort” (ChiCTR 2,000,032,949). The TyG index was calculated as ln [fasting triglyceride (mg/dL) ╳ fasting plasma glucose (mg/dL)/2] and group-based trajectory model (GBTM) was applied to identify the trajectory of TyG index. The association between different trajectory groups of TyG index with frailty risk were estimated using multinomial logistic regression analysis. Results In the cross-sectional analysis, the highest quartile of the TyG index was associated with an increased risk of frailty (TyG index Q4 vs. Q1, OR = 1.50, 95% CI 1.00–2.25, P = 0.048). Restricted cubic splines demonstrated an increasing trend for TyG index and frailty risk. During a follow-up of ten years, three distinct trajectories of the TyG index were identified: low-stable (n = 697, 38.3%), moderate-stable (n = 910, 50.0%) and high-stable (n = 214, 11.7%). Compared with those in the stable-low group of TyG index trajectory, the ORs (95% CI) of prefrailty and frailty risk were 1.79 (95% CI 1.11–2.88) and 2.17 (95% CI 1.01–3.88) for the high-stable group, respectively (P = 0.017 and P = 0.038). In the subgroup analysis, the association of the high-stable trajectory of TyG and frailty status were only observed in subjects with BMI ≥ 24 kg/m2. Prospectively, the highest quartile of the TyG index was associated with a 2.09-fold significantly increased risk of one-year ADL/IADL decline (P = 0.045). Conclusions The present study suggests a potential role for a high and sustainable level of TyG index in the risk of frailty. The trajectories of the TyG index can help to identify older individuals at a higher risk of frailty who deserve primitive preventive and therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Yuan,

Chen,

Lin

et al. 2023

Cardiovasc Diabetol

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“…Insulin resistance leads to impaired glucose metabolism and accelerated vascular calcification by blocking signaling pathways mediated by insulin receptors on the cell membranes of vascular smooth muscle cells, endothelial cells, and macrophages [ 14 , 33 ]. In addition, our previous study showed that sarcopenia is a common complication and is closely related to insulin resistance in non-diabetic patients undergoing MHD [ 34 ]. Sarcopenia can cause decreased expression of myokines, such as irisin, and low irisin is an independent risk factor for vascular calcification [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis

et al. 2023

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Objective Coronary artery calcification (CAC) is positively and independently associated with cardiovascular disease (CVD) in patients undergoing maintenance hemodialysis (MHD). Insulin resistance is independently associated with CAC and is an important risk factor for CVD. The triglyceride–glucose (TyG) index is a reliable biomarker of insulin resistance. This cross-sectional, observational study aimed to investigate the relationship between the TyG index and CAC in asymptomatic non-diabetic patients undergoing MHD. Methods The quantitative coronary artery calcification score (CACS) was calculated and expressed using the Agatston score. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multiple Poisson regression analysis, Spearman correlation analysis, and receiver operating characteristic (ROC) curves were used to investigate the relationship between the TyG index and CAC. Results The 151 patients were divided into three groups according to the tertiles of the TyG index. With an increase in the TyG index, the CACS significantly increased (Spearman’s rho = 0.414, p < 0.001). Poisson regression analysis indicated that the TyG index was independently related to the presence of CAC (prevalence ratio, 1.281 [95% confidence interval, 1.121–1.465], p < 0.001). Furthermore, ROC curve analysis showed that the TyG index was of value in predicting the CAC in asymptomatic non-diabetic patients undergoing MHD, with an area under the curve of 0.667 ( p = 0.010). Conclusion The TyG index is independently related to the presence of CAC in asymptomatic, non-diabetic patients undergoing MHD.

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“…Ahn et al reported that higher TyG index values were found to be associated with an increased risk of low skeletal muscle mass index in Korean adults [20] . Other studies also showed that elevated levels of TyG index are a risk factor for reduced muscle mass or strength [21,22] , even in adolescents between the ages of 12 and 18 [36] . In addition to evidence from cross-sectional studies, post hoc analyses of a prospective study suggested that baseline lower handgrip strength levels were inversely associated with the three-year follow-up TyG index values, which indicate that handgrip strength can be a predictor of future insulin resistance [23] .…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence indicated that the TyG index is associated with cardiovascular and metabolic risk, predominantly cardiovascular disease [8][9][10][11] , type 2 diabetes mellitus [12] , stroke [13,14] , arterial stiffness [11,15,16] , vascular damage [17,18] and even death [19] . Recently, a few studies reported that a higher TyG index was also associated with an increased risk of sarcopenia or low muscle mass in older populations [20][21][22] . Zheng et al also claimed that handgrip strength per weight was inversely associated with TyG index in the elderly population [23] .…”

Section: Introductionmentioning

confidence: 99%

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Yuan

Chen

Lin

et al. 2023

Preprint

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Background Frailty is an age-related geriatric syndrome that leads to a series of clinically negative events. A better understanding of the factors associated with frailty assists in preventing its progression. The triglyceride-glucose (TyG) index, a simple alternative index of insulin resistance, has not yet been proven to be associated with frailty. The present study aimed to investigate the association between the TyG index and its trajectory with frailty from a cross-sectional, retrospective and prospective level based on an ongoing cohort. Methods This longitudinal study included 1,866 older residents from the “Fujian prospective aging cohort” (ChiCTR 2000032949). The TyG index was calculated as ln [fasting triglyceride (mg/dL) ╳ fasting plasma glucose (mg/dL)/2] and group-based trajectory model (GBTM) was applied to identify the trajectory of TyG index. The association between different trajectory groups of TyG index with frailty risk were estimated using multinomial logistic regression analysis. Results In the cross-sectional analysis, the highest quartile of the TyG index was associated with an increased risk of frailty (TyG index Q4 vs. Q1, OR = 1.50, 95% CI 1.00–2.25, P = 0.048). Restricted cubic splines demonstrated an increasing trend for TyG index and frailty risk. During a follow-up of ten years, three distinct trajectories of the TyG index were identified: low-stable (n=697, 38.3%), moderate-stable (n=910, 50.0%) and high-stable (n=214, 11.7%). Compared with those in the stable-low group of TyG index trajectory, the ORs (95% CI) of prefrailty and frailty risk were 1.79 (95% CI 1.11–2.88) and 2.17 (95% CI 1.01–3.88) for the high-stable group, respectively (P=0.017 and P=0.038). In the subgroup analysis, the association of the high-stable trajectory of TyG and frailty status were only observed in subjects with BMI ≥24kg/m2. Prospectively, the highest quartile of the TyG index was associated with a 2.09-fold significantly increased risk of one-year ADL/IADL decline (P = 0.045). Conclusions The present study suggests a potential role for a high and sustainable level of TyG index in the risk of frailty. The trajectories of the TyG index can help to identify older individuals at a higher risk of frailty who deserve primitive preventive and therapeutic approaches.

show abstract

The triglyceride-glucose index as a novel marker associated with sarcopenia in non-diabetic patients on maintenance hemodialysis

Cited by 9 publications

References 44 publications

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis

Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study

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