The tumour necrosis factor-alpha inhibitor adalimumab rapidly reverses the decrease in epidermal Langerhans cell density in psoriatic plaques

Gordon, Kenneth B.; Bonish, Brian K.; Patel, Toral; Nickoloff, Brian J.

doi:10.1111/j.1365-2133.2005.06816.x

Cited by 59 publications

(56 citation statements)

References 43 publications

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“…Deguchi et al, showed that the number of CD1a-positive epidermal langerhans cells in psoriatic lesions was not significantly different from that of normal controls, while we found higher epidermal CD1a+ cells infiltrate in lesional and non lesional skin than in controls [16]. Other studies reported variable results [17,18]. Recent evidences suggest impaired migration of Langerhans cells in early onset psoriasis [19].…”

Section: Discussioncontrasting

confidence: 36%

Immunophenotypic Evaluation of Skin in Psoriasis A Case Control Study

Meena¹

2015

CDT

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BackgroundPathogenesis of psoriasis is complex. Latest evidences suggest the role of T-lymphocytes (CD4+, CD8+, and CD45RO+ memory T cells), Langerhans cells (CD1a+) and VEGF in the altered keratinocytes kinetics. Aims and objectivesTo evaluate the extent of infiltration of T-lymphocytes (CD4+, CD8+, CD45RO+), Langerhans cells (CD1a+) and VEGF in lesional and non lesional skin in psoriatic patients and healthy controls. Materials and methodsTwenty-five untreated psoriasis cases were taken up for study. Five millimeter biopsies of the patient's skin were taken from the newest Psoriasis Lesion (PL) and the farthest non-lesional skin (PN). They were stained with H&E (Hematoxylin and Eosin stain) and with monoclonal antibody against CD4+, CD8+, CD45RO+ T cells, CD1a+ and VEGF. Skin biopsies of 5 healthy controls were also subjected to the same stain. ResultsOn hematoxylin and eosin staining, the degree of cellular infiltrate was more in PL dermis than PL epidermis, while similar degree of cellular infiltrate was found in PN epidermis and dermis. Dermal vascular proliferation was also higher in PL than in PN. On immunohistochemical evaluation, epidermal infiltrate of CD4+ T cells, CD8+ T cells and CD1a+ cells were more abundant in PL than in PN. Also, VEGF was more expressed in the epidermis of PL than in PN. However, CD45RO+ T cells were more in the dermis of PL than in PN. When comparing PL and PN with healthy controls, there was increased infiltration of all markers when compared to controls. ConclusionThe inflammatory process in psoriasis involves the whole skin of the patient, but is more pronounced in the damaged skin.

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Section: Discussioncontrasting

confidence: 36%

Immunophenotypic Evaluation of Skin in Psoriasis A Case Control Study

Meena¹

2015

CDT

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“…The return to the normal organization of epidermis resulted in reappearance of LCs -common constituent of basal and suprabasal layers. Similar effect was observed in psoriatic lesional skin after adalimumab -TNF-α inhibitor [40] and cyclosporine A [41], however Prignano et al [42] reported a 70% decrease of LCs number in psoriatic plaques 4 months after biological therapies. Normalization of the distribution of LCs in psoriasis was reported after systemic aromatic retinoid i.e.…”

Section: Density Of Langerhans Cells In Chronic Plaque Psoriatic Lesimentioning

confidence: 61%

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Rotsztejn¹,

Chomiczewska²,

Trznadel-Grodzka³

et al. 2012

cejoi

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“…Moreover, though the frequency and morphology of epidermal LCs in uninvolved skin of psoriatics is normal, these cells present impaired migration in response to stimuli such as allergens [27]. Whether the alterations in LC density in psoriatic plaques and the impaired LC migration from uninvolved skin influence contact sensitivity and PT reactivity remains to be determined [26, 27]. …”

Section: Discussionmentioning

confidence: 99%

“…Previous immunologic studies indicated that psoriatics have a decreased prevalence of sensitization to experimental allergens and prolonged time of sensitization, and a higher allergen concentration is required to elicit an allergic response [20, 24, 25]. In the psoriatic plaque, compared with uninvolved skin of patients with psoriasis, CD1a+ CD207+ Langerhans cells (LCs), a type of immature dendritic cell in the epidermis, are present at reduced density [26]. Moreover, though the frequency and morphology of epidermal LCs in uninvolved skin of psoriatics is normal, these cells present impaired migration in response to stimuli such as allergens [27].…”

Section: Discussionmentioning

confidence: 99%

Contact Sensitivity in Patients with Psoriasis in Vojvodina

Jovanović

Boża²,

Karadaglić

et al. 2008

Int Arch Allergy Immunol

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Background: Immunologic studies indicate that psoriasis may represent an organ-integrated response. Objective: We assessed contact hypersensitivity in plaque-type psoriasis, its frequency, etiology and association with severity of psoriasis. Methods: Contact hypersensitivity was defined as a positive patch test (PT) to at least one of 44 ubiquitous contact allergens. Patients with exclusively plaque psoriasis and control groups (patients with allergic contact or extrinsic atopic dermatitis and healthy persons) were tested with the European standard series; plant-related standard allergens; Compositae allergens, and our own extracts from Compositae plants ubiquitous in Vojvodina. Sensitization rates to allergens were standardized for age and sex, and rates in women and in men were both standardized for age. Disease severity was evaluated using the Psoriasis Area Severity Index score. Results: 15,123 PTs were performed. Among psoriatic patients in Vojvodina, the overall rate of sensitivity, standardized for age and sex, was 18.9%. Rates in women (27.7%) and men (5.8%), both standardized for age, were significantly different. Male psoriatic patients reacted less than healthy males, the difference being on the margin of significance. There was no relationship between severity of disease and PT reactivity. Yarrow extract, nickel and a Compositae mix were the most common allergens that produced positive reactions. Conclusion: Although patch testing in psoriatic patients can be quite challenging, time-consuming and difficult, it will provide further insight into the pathophysiology of psoriasis. Factors other than different exposure to allergens may also be responsible for a sex-related difference in contact sensitivity. Future studies should focus on this field.

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The tumour necrosis factor-alpha inhibitor adalimumab rapidly reverses the decrease in epidermal Langerhans cell density in psoriatic plaques

Cited by 59 publications

References 43 publications

Immunophenotypic Evaluation of Skin in Psoriasis A Case Control Study

Immunophenotypic Evaluation of Skin in Psoriasis A Case Control Study

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Contact Sensitivity in Patients with Psoriasis in Vojvodina

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