The Two Faces of Selenium - Can Selenophobia Be Cured?

Frost, Douglas V.

doi:10.3109/10408447209103467

Cited by 101 publications

(32 citation statements)

References 135 publications

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“…Further, studies of selenium deficiency in man (64) and pigs (65,66)-the deficiency is associated with myocardial and vascular damage-and a study of the effect of selenium and vitamin E on myocardial necrosis induced by isoprenaline treatment or coronary artery ligation (67) indicate that free radical reactions are continuously present in the cardiovascular system and that the rate of accumulation of damage produced by them is limited to tolerable values largely by glutathione peroxidase. Likewise, the incidence of the common forms of cardiovascular disease is low in areas where the dietary intake of selenium is high and vice versa (49,68,69). The ability of glutathione peroxidase to "buffer" free radical reaction damage may largely account for the inconclusive results (70) obtained in studies designed to alter atherogenesis rates in minipigs by diets formulated to change the level offree radical reactions in the serum; the diets contained varying amounts of polyunsaturated fats and of copper.…”

Section: )mentioning

confidence: 99%

The aging process.

Harman¹

1981

Proc. Natl. Acad. Sci. U.S.A.

1,582

672

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Aging is the progressive accumulation of changes with time that are associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age. These time-related changes are attributed to the aging process. The nature ofthe aging process has been the subject ofconsiderable speculation. Accumulating evidence now indicates that the sum ofthe deleterious free radical reactions going on continuously throughout the cells and tissues constitutes the aging process or is a major contributor to it. In mammalian systems the free radical reactions are largely those involving oxygen.Dietary manipulations expected to lower the rate of production of free radical reaction damage have been shown (i) to increase the life span of mice, rats, fruit flies, nematodes, and rotifers, as well as the "life span" of neurospora; (#-) to inhibit development ofsome forms ofcancer; (ii) to enhance humoral and cell-mediated immune responses; and (iv) to slow development of amyloidosis and the autoimmune disorders of NZB and NZB/NZW mice. In addition, studies strongly suggest that free radical reactions play a significant role in the deterioration of the cardiovascular and central nervous systems with age.The free radical theory of aging provides reasonable explanations for age-associated phenomena, including (i) the relationship of the average life spans of mammalian species to their basal metabolic rates, (ii) the clustering of degenerative diseases in the terminal part of the life span, (iii) the beneficial effect of food restriction on life span, (iv) the greater longevity of females, and (v) the increase in autoimmune manifestations with age.

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Section: )mentioning

confidence: 99%

The aging process.

Harman¹

1981

Proc. Natl. Acad. Sci. U.S.A.

1,582

672

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“…Selenium was firstly-and explicitly-ascribed an essential role in mammalian nutrition by Schwarz and Foltz (1957), even if it still took another one and a half decade for, independently yet almost simultaneously, glutathione peroxidase (GSHPx) to be recognised as a selenoenzyme (Flohé et al 1973), and Se itself as a key biochemical regulator for the GSHPx antioxidant activity (Rotruck et al 1973). Following those major breakthroughs, and in one of the more dramatic twists in modern science, selenophobia (Frost 1972) quickly turned into selenophilia (Casey 1988), to the point that, by 1996, this new face of Se had already been the subject of over 100000 technical papers (Reilly 1996).…”

Section: Introductionmentioning

confidence: 99%

Characterization of selenium-enriched wheat by agronomic biofortification

et al. 2014

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Agronomic biofortification of staple crops is an effective way to enhance their contents in essential nutrients up the food chain, with a view to correcting for their deficiencies in animal or human status. Selenium (Se) is one such case, for its uneven distribution in the continental crust and, therefore, in agricultural lands easily translates into substantial variation in nutritional intakes. Cereals are far from being the main sources of Se on a content basis, but they are likely the major contributors to intake on a dietary basis. To assess their potential to assimilate and biotransform Se, bread and durum wheat were enriched with Se through foliar and soil addition at an equivalent field rate of 100 g of Se per hectare (ha), using sodium selenate and sodium selenite as Se-supplementation matrices, in actual field conditions throughout. Biotransformation of inorganic Se was evaluated by using HPLC−ICP-MS after enzymatic hydrolysis for Se-species extraction in the resulting mature wheat grains. Selenomethionine and Se VI were identified and quantified: the former was the predominant species, representing 70-100 % of the total Se in samples; the maximum amount of inorganic Se was below 5 %. These results were similar for both supplementation methods and for both wheat varieties. Judging from the present results, one can conclude that agronomic biofortification of wheat may improve the nutritional quality of wheat grains with significant amounts of selenomethionine, which is an attractive option for increasing the Se status in human diets through Se-enriched, wheat-based foodstuff.

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“…V okolju se nahaja v anorganski obliki (elementarni selen: Se, selenid: Se (Pyrzyńska, 2002;Uden s sod., 2004). Frost (1972) opisuje dinamično ravnotežje in pretvarjanje med anorganskimi in organskimi oblikami selena.…”

Section: Selen V Okoljuunclassified

Plant Resources Based Selenium Supplementation in Daily Nutrition

Škrabanja¹

2017

AAS

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IZVLEČEKSelen je eden izmed esencialnih elementov, potrebnih za človekovo zdravje. Razmere v okolju in kmetijska praksa imajo velik vpliv na vsebnost selena v rastlinah. Gojenje rastlin, obogatenih s selenom, je učinkovit način dodajanja selena v vsakdanjo prehrano tistih, ki tega esencialnega elementa ne prejmejo v zadostnih količinah. Biorazpoložljivost selena je v korelaciji z izvorom in s kemijsko obliko, v kateri je ta prisoten v živilu. S prehranskega vidika so s selenom obogatena živila potencialni dodatni vir selena, ki se vnaša v organizem preko prehranske verige in se s kompleksnimi pretvorbami na molekulski ravni pretvarja iz anorganskih v bolj razpoložljive organske oblike. V članku so zbrani rezultati sistematičnega raziskovanja vsebnosti selena v posameznih rastlinskih vrstah in različnih načinov dodajanja selena za dosego večje koncentracije letega v pridelku. V Sloveniji so tla s selenom revna in je možnost pomanjkanja selena v prehrani nekaterih skupin prebivalstva velika. Zato je v članku večji poudarek namenjen pregledu objavljenih del domačih strokovnjakov, ki so vsebnost selena spremljali ob simulaciji sprememb okoljskih dejavnikov, kar je dodatno vplivalo na fiziološke lastnosti in pridelek rastlin. Upoštevana je pozitivna vloga selena v presnovi človeka ter njegov vpliv na zdravje. Omenjeni so tudi negativni vplivi zaradi pomanjkanja ali presežka selena v hrani, ki opozarjajo na to, da je treba priporočila v zvezi z vnosom selena v naš organizem temeljito spremljati in premišljeno prilagajati referenčne vrednosti.Ključne besede: selen; rastlinski viri; prehranski vnos; dodatek selena ABSTRACT PLANT RESOURCES BASED SELENIUM SUPPLEMENTATION IN DAILY NUTRITIONSelenium is one of the essential elements that has a direct effect on human health and disease. Environmental conditions and agricultural practice have a profound influence on the selenium content in plants. Cultivation of plants enriched with the selenium has an effective potential for selenium supplementation in diets for population which is exposed to selenium deficiency. Bioavailability of selenium compounds from food is in strong correlation with the source and its chemical form. The selenium of different sources and forms can become a part of human consumption when entering the food chain, wherein the inorganic forms of selenium are metabolized and converted to more available organic forms. Numerous results of systematic research of the selenium content in individual plant species as well as various techniques for producing selenium enriched foodstuffs is reviewed. The soil in Slovenia is selenium-poor and may concern a part of population which is potentially sensitive to selenium status. The merits of selenium effect, either alone or in combination with different environmental changes on plant production published by Slovenian authors are thus closely considered. Controversies continue to prevail regarding adequate amounts for selenium for health and disease prevention.Thus, general and individualized recommendations for selenium ...

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The Two Faces of Selenium - Can Selenophobia Be Cured?

Cited by 101 publications

References 135 publications

The aging process.

The aging process.

Characterization of selenium-enriched wheat by agronomic biofortification

Plant Resources Based Selenium Supplementation in Daily Nutrition

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