The two suborders of chiropterans have the canonical heavy-chain immunoglobulin (Ig) gene repertoire of eutherian mammals

The immune gene repertoire of an important viral reservoir, the Australian black flying fox

“…These included heavy chain genes encoding IgA, IgG, IgM and IgE, which have previously been described in the megabat, Cynopterus sphinx . No evidence for the transcription of IgD was observed in the P. alecto transcriptome, a result which is consistent with C. sphinx [67]. The two light chain subtypes, kappa and lambda and a variety of B cell co-receptors including CD19, CD22, CD72, CD79a and CD79b were also identified in our datasets (Additional file 3).…”

Mucosal Immunoglobulins

“…The primary amino acid structures of α chains of human (both subclasses and allotypes), gorilla, chimpanzee, orangutan, gibbon, macaque, sooty mangabey, dog, pig, goat, sheep, horse, dolphin, bat, rabbit, mouse, rat, cow, possum, duckbill platypus, echnida, quail, pheasant, turkey, chicken, duck, goose, ostrich, alligator, and crocodile IgA have been obtained by amino acid and/or DNA sequence analyses, and IgA-like antibodies have been identified in leopard geckos Burnett et al, 1989;Kawamura et al, 1991Kawamura et al, , 1992Patel et al, 1995;Brown and Butler, 1994;Knight et al, 1984;Kratzin et al, 1975;Mansikka, 1992;Putnam et al, 1979;Torano and Putnam, 1978;Tsuzukida et al, 1979;Tucker et al, 1981;Yang et al, 1979;Brown et al, 1997;Belov et al, 2002;Lundquist et al, 2001;Wagner et al, 2003;White et al, 1998;Zhou et al, 2005Zhou et al, , 2006Scinicariello et al, 2006;Mancia et al, 2007;Deza et al, 2007;Choi et al, 2010;Vernersson et al, 2010;Butler et al, 2011;Huang et al, 2012;Guo et al, 2014;Cheng et al, 2013;Magadan-Mompo et al, 2013a). Aligned sequences of IgA from selected species are shown in Figure 3.…”

“…The genes for the heavy chain of IgA have been cloned from several species, including humans (Flanagan et al, 1984), nonhuman primates (Kawamura et al, 1989(Kawamura et al, , 1990Ueda et al, 1988;Scinicariello et al, 2006;Rogers et al, 2008), rodents (Tucker et al, 1981;Bruggemann et al, 1986), bats (Butler et al, 2011), pets and domesticated animals (Knight et al, 1988;Burnett et al, 1989;White et al, 1998;Brown and Butler, 1994;Wagner et al, 1997;Patel et al, 1995;Zhou et al, 2006), dolphins (Mancia et al, 2007), marsupials (Aveskogh and Hellman, 1998), monotremes (Belov et al, 2002;Vernersson et al, 2010), and birds (Mansikka, 1992;Magor et al, 1998;Choi et al, 2010;Huang et al, 2012;Guo et al, 2014), in some cases as part of species genome projects. Thus, DNA sequence information for IgA is available for a wide range of mammalian and an increasing number of bird species.…”

Resolution of an immunodiagnostic dilemma: Heavy chain chimeric antibodies for species in which plasmocytomas are unknown

“…In these tiny bats and from other species in this category, the amount of serum that would be needed for physical chemical purification of any Ig would be in violation of animal use guidelines. However, Ig gene sequences are available for these and most all of the species listed in Table 1 Butler et al, 2011).…”