The ultrasonic properties of gastric cancer tissues obtained with a scanning acoustic microscope system

Saijo, Yoshifumi; Tanaka, Motonao; Okawai, Hiroaki; Dunn, F.

doi:10.1016/0301-5629(91)90103-4

Cited by 84 publications

(25 citation statements)

References 3 publications

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“…Acoustic microscopy for medicine and biology has been developed for more than twenty years at Tohoku University [1][2][3][4][5][6]. The application of acoustic microscopy in medicine and biology has three major features and objectives.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic intensity microscopy for imaging of living cells

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Ultrasonic intensity microscopy for imaging of living cells

et al. 2009

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“…A specially developed scanning acoustic microscope (SAM) system (Okawai et al 1987(Okawai et al ,1988Saijo et al 1991) has been used to determine quantitatively the ultrasonic properties of the infarcted myocardium,…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic tissue characterization of infarcted myocardium by scanning acoustic microscopy

Saijo

Tanaka

Okawai

et al. 1997

Ultrasound in Medicine & Biology

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126

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Abstract-The purpose of this study was to ultrasonically characterize infarcted human myocardial tissue at the microscopic level by scanning acoustic microscopy. Infarcted myocardial specimens from ten cases with acute myocardial infarction were studied. Specimens were formalin fixed, para& embedded and sectioned to lo-pm thickness. A specially developed scanning acoustic microscope system, operating in the lOO-to 200-MHz ultrasound frequency range, was used for the measurements.

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“…Previous research suggested that backscatter from tumors was in some cases highly dependent on the organization of the cells in the tumor [14,15]. Closer examination of the photomicrographs of the carcinomas and sarcomas (Fig.…”

Section: Envelope Statisticsmentioning

confidence: 93%

11B-4 Quantitative Ultrasound Assessment of Breast Cancer Using a Multiparameter Approach

Oelze

O’Brien

Zachary

2007

2007 IEEE Ultrasonics Symposium Proceedings

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Early detection and diagnosis of breast cancer leads to improved prognosis. Quantitative ultrasound (QUS) techniques utilizing a multiparameter set have been developed for classifying rodent models of breast cancer. The improvement in detection and diagnosis of breast cancer using QUS will have significant medical impact. Two kinds of mammary tumors, carcinoma and sarcoma, were examined in mice using QUS imaging. Ten tumors for each kind of cancer were scanned with a 20-MHz singleelement transducer (f/3). The tumors contained microstructural differences in size, shape, and organizational patterns of the scatterers. Cells were identified as a prominent source of scattering in the tumors. The average scatterer diameter (ASD) and average acoustic concentration (AAC) were estimated by comparing the normalized backscattered power spectra from the tumors with newly developed models of cell scattering. The organizational structure of the tumors was also characterized by a clustering parameter (the β parameter) and the randomness of the scatterer locations (the S parameter) by comparing the envelope statistics of the backscatter to a homodyned-K distribution. F-tests conducted on the backscattered power spectra from the two kinds of tumors revealed statistically significant differences for frequencies above 16 MHz. QUS images of the tumors utilizing the ASD, AAC, β, and S parameter estimates from the new model and the envelope statistics were constructed. Statistically significant differences were observed between the carcinomas and sarcomas for all estimated parameters for ultrasonic frequencies above 16 MHz. Feature analysis plots incorporating all four parameters indicated cancer classification was improved compared with analysis using only two parameters. High-frequency QUS utilizing a multiparameter feature set improved the diagnostic potential of ultrasound for breast cancer detection. (Supported by NIH Grants CA 079179 and CA111289)

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The ultrasonic properties of gastric cancer tissues obtained with a scanning acoustic microscope system

Cited by 84 publications

References 3 publications

Ultrasonic intensity microscopy for imaging of living cells

Ultrasonic intensity microscopy for imaging of living cells

Ultrasonic tissue characterization of infarcted myocardium by scanning acoustic microscopy

11B-4 Quantitative Ultrasound Assessment of Breast Cancer Using a Multiparameter Approach

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