The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

Zhang, Kezhong; Wong, Hetty N.; Song, Benbo; Miller, Corey N.; Scheuner, Donalyn; Kaufman, Randal J.

doi:10.1172/jci21848

Cited by 170 publications

(148 citation statements)

References 70 publications

Supporting

Mentioning

146

Contrasting

Order By: Relevance

“…Staron et al described the essential role of GRP94 during the pro to pre-B-cell transition. Interestingly, this stage was previously identified by Zhang et al to depend on IRE1 [42].…”

Section: Resultsmentioning

confidence: 68%

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

et al. 2013

View full text Add to dashboard Cite

“…Staron et al described the essential role of GRP94 during the pro to pre-B-cell transition. Interestingly, this stage was previously identified by Zhang et al to depend on IRE1 [42].…”

Section: Resultsmentioning

confidence: 68%

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

et al. 2013

View full text Add to dashboard Cite

“…IRE1a À/À embryos display broad and severe developmental deficiencies and generally die after 12.5 days of gestation (Zhang et al, 2005). This embryonic lethality is thought to occur through compromised expression of placental VEGF in IRE1a À/À mice, which leads to a consequent reduction in the blood space of the labyrinth layer of the placenta (Iwawaki et al, 2009), an area responsible for exchange of oxygen and nutrients at the mother-fetus interface.…”

Section: The Upr and Embryonic Vascularizationmentioning

confidence: 99%

ER Stress and Angiogenesis

2015

View full text Add to dashboard Cite

Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth. In this regard, the classical pathways of the unfolded protein response activated under conditions of ER stress have recently been described to generate angiomodulatory or angiostatic signals. This review elaborates on the link between angiogenesis and ER stress and discusses the implications for diseases characterized by altered vascular homeostasis, such as cancer, retinopathies, and atherosclerosis.

show abstract

“…In particular, the IRE1-XBP1 branch of UPR plays a crucial role. It is based on the facts that (1) IRE1-deficient B cells do not differentiate into plasma cells in vitro [23], (2) XBP1-deficient B cells fail to differentiate into plasma cells in vivo [24] and (3) ectopic expression of the spliced form of XBP1 restores immunoglobulin production in XBP1-deficient B cells in vitro [25].…”

Section: Plasma Cellmentioning

confidence: 99%

Endoplasmic reticulum stress in the kidney

Kitamura

2008

Clin Exp Nephrol

View full text Add to dashboard Cite

Endoplasmic reticulum (ER) stress is involved in a wide range of pathological circumstances including neurodegenerative disorders, diabetes mellitus, ischemic injury, cancers, atherosclerosis, inflammation, infection, toxicity of chemicals and metals, and psychotic diseases. ER stress is also involved in some physiological events including development of particular cell types. A number of pathophysiological triggers cause accumulation of unfolded proteins in the ER, i.e., ER stress. In response to accumulation of unfolded/misfolded proteins, cells adapt themselves to the stress conditions via a coordinated adaptive program, the unfolded protein response (UPR). UPR is a double-edged sword. It induces both prosurvival and proapoptotic signaling. It also triggers both proinflammatory and anti-inflammatory signals. In this review, I summarize current knowledge on putative, pathophysiological roles of ER stress in the kidney.

show abstract

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

Cited by 170 publications

References 70 publications

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

ER Stress and Angiogenesis

Endoplasmic reticulum stress in the kidney

Contact Info

Product

Resources

About