The unique antibody suppresses HBV viremia and reduces hepatocarcinogenesis in HBV-transgenic mice

Kang, Xiao-Zhen; Guo, Xue-Ran; Chen, Bin-Bing; Zhang, Tianying; Yuan, Quan; Chen, Pei‐Jer; Zhang, Jun; Xia, Ningshao

doi:10.1080/21645515.2018.1449553

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2021

Publication Types

Select...

Article3

Relationship

Self Cite1

Independent2

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 10 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A chimeric VLP displaying multiple epitopes will stimulate stronger epitope-specific antibody responses that can mediate HBsAg clearance in vivo. In our previous study, we found that not all antibodies against HBsAg demonstrated an equal ability to clear HBV in vivo; only E6F6-like antibodies recognising the unique sA epitope (HBsAg-aa119-125 as the core motif) could potently mediate HBsAg clearance 24–26. Previous findings suggest that the epitope is the key factor that determines the efficacy of anti-HBsAg antibodies, and the sA epitope has potential to be a therapeutic target against CHB.…”

Section: Introductionmentioning

confidence: 97%