The Unique Neonatal NK Cells: A Critical Component Required for Neonatal Autoimmune Disease Induction by Maternal Autoantibody

Rival, Claudia; Setiady, Yulius Y.; Samy, Eileen T.; Harakal, Jessica; Tung, Kenneth S. K.

doi:10.3389/fimmu.2014.00242

Cited by 8 publications

(6 citation statements)

References 63 publications

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“…Importantly, it is demonstrated that expression of NK cells’ receptors plays a pivotal role in host susceptibility to autoimmune and inflammatory diseases. It is documented that expression of receptors in NK cells (e.g., LY49 and NKG2A) is highly regulated during ontogeny and whole lifetime ( 13 ). Both human and animal studies have indicated that the balance between stimulatory and inhibitory receptors plays a central role in susceptibility, function, interaction, and activation of of NK cells ( 13 , 14 ).…”

Section: The Status Of Neonatal Immune Systemmentioning

confidence: 99%

Innate Immunity of Neonates and Infants

et al. 2018

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Many important events occur at birth. The fetus is suddenly removed from a protected intra-uterine environment that is aquatic, warm, and nearly sterile, to the dry, cold external world laden with microbes. To survive, the neonate must interact with many organisms, making use of some, while vigorously defending against the others like a nation conducting trade with friendly countries and guarding against hostile ones from invading it, waging wars if necessary. Although, the neonatal immune system is plastic, however, it is highly tolerant which is due to both the fetal development during gestation as well as significant sudden changes in fetal environment and enormous exposure to the new antigens and intestinal bacteria and their products. This “quiescent mode” of innate immune system is part of a highly regulated process to fulfill all requirements of multi-layered process of early life, implemented effectively through the cells of innate immune system. While, most of the neonatal innate immune cells (e.g., neutrophils and monocytes) present contained activity and lower frequencies compared to their adult counterparts, innate lymphoid cells (ILCs), a distinct cellular component of innate immunity, show higher level of activity and presence during period of infancy compared to later stages of life and adulthood, which may suggest a role for ILCs in variable susceptibility to certain conditions during life time. In this review, while we focus on the characteristics and status of ILCs in neonatal immune system, we also draw an analogy from a national defense perspective because of the great similarities between that and the immune system by providing the known biological counterparts of all five core operational elements, the five Ds of defense, detection, discrimination, deployment, destruction, and de-escalation, with special focus on innate immunity, maternal support, and influence during the neonatal and infancy periods.

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Section: The Status Of Neonatal Immune Systemmentioning

confidence: 99%

Innate Immunity of Neonates and Infants

et al. 2018

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“…Nevertheless, interactions between ICs and neonatal versus adult innate and adaptive immune systems still need to be investigated because mouse studies have revealed potential antibody-induced neonatal autoimmunity in certain settings. 85,86…”

Section: Rsvmentioning

confidence: 99%

Converting monoclonal antibody-based immunotherapies from passive to active: bringing immune complexes into play

Lambour

Naranjo-Gómez

Piechaczyk

et al. 2016

Emerging Microbes & Infections

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Monoclonal antibodies (mAbs), which currently constitute the main class of biotherapeutics, are now recognized as major medical tools that are increasingly being considered to fight severe viral infections. Indeed, the number of antiviral mAbs developed in recent years has grown exponentially. Although their direct effects on viral blunting have been studied in detail, their potential immunomodulatory actions have been overlooked until recently. The ability of antiviral mAbs to modulate antiviral immune responses in infected organisms has recently been revealed. More specifically, upon recognition of their cognate antigens, mAbs form immune complexes (ICs) that can be recognized by the Fc receptors expressed on different immune cells of infected individuals. This binding may be followed by the modulation of the host immune responses. Harnessing this immunomodulatory property may facilitate improvements in the therapeutic potential of antiviral mAbs. This review focuses on the role of ICs formed with different viral determinants and mAbs in the induction of antiviral immune responses in the context of both passive immunotherapies and vaccination strategies. Potential deleterious effects of ICs on the host immune response are also discussed.

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“…A review on the unique neonatal NK cell population and its role in gestational autoimmunity is provided by Rival et al ( 12 ) from Kenneth Tung’s group. Maternal autoantibodies can trigger autoimmune ovarian disease (AOD) in the progeny of women with SLE or Sjogren’s syndrome.…”

mentioning

confidence: 99%