2016
DOI: 10.1016/j.bbrc.2016.08.120
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The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition

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Cited by 71 publications
(66 citation statements)
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“…Unigene56159 can act as a competing endogenous RNA to decrease the expression of Slug by interacting with miR-140-5p [31]. In addition, upregulation of colon cancer-associated transcript 2 predicts poor prognosis in patients with prostate cancer and promotes metastasis by regulating the EMT [32]. In this study, we found that LncDQ promoted cell proliferation and motility via the EMT pathway, indicating that LncDQ acts as an oncogene in HCC.…”
Section: Discussionmentioning
confidence: 68%
“…Unigene56159 can act as a competing endogenous RNA to decrease the expression of Slug by interacting with miR-140-5p [31]. In addition, upregulation of colon cancer-associated transcript 2 predicts poor prognosis in patients with prostate cancer and promotes metastasis by regulating the EMT [32]. In this study, we found that LncDQ promoted cell proliferation and motility via the EMT pathway, indicating that LncDQ acts as an oncogene in HCC.…”
Section: Discussionmentioning
confidence: 68%
“…Remarkably, other studies also demonstrated that CCAT1 or CCAT2 knockdown through siRNAs inhibit cell growth, migration, and invasion in PC-3 and DU145 cells [21,43], indicating that CCAT1/2 silencing mimics VIRMA knockdown in metastatic androgen-independent PCa cells.…”
Section: Discussionmentioning
confidence: 85%
“…Only two studies reported no association between increased CCAT2 expression and LNM in prostate cancer and bladder cancer, respectively, which might be caused by the small size or the tumor type 17, 23. The mechanism on regulatory activity of CCAT2 in cancer invasion and metastasis has been explored in several cancer types.…”
Section: Discussionmentioning
confidence: 99%
“…High expression of CCAT2 has been reported associated with metastasis and prognosis in different types of cancer, which indicated the diagnostic or prognostic value of CCAT2 for cancer 13-16, 20, 22, 23. However, the results from each study were insufficient and not completely consistent in the correlation between CCAT2 and the clinical metastatic factors (as lymph node metastasis (LNM) and distance metastasis (DM)) or prognostic factors (like OS and progression free survival (PFS)).…”
Section: Introductionmentioning
confidence: 99%