The uptake by the canine tibia of the bone-scanning agent 99mTc-MDP before and after an osteotomy

Hughes, Sean; Khan, Ralph A. A.; Davies, Rob; Lavender, Peter

doi:10.1302/0301-620x.60b4.711811

Cited by 32 publications

(12 citation statements)

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“…The relationship between blood flow and tracer uptake after a fracture has been examined in detail but there is still disagreement about whether the uptake is completely determined by increased flow or whether there are other factors involved [2][3][4]. One reason for this agreement appears to be that the relationship between flow and uptake is not necessarily constant.…”

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confidence: 99%

The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate

McCarthy

Hughes

1983

Calcif Tissue Int

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The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow in normal canine tibia. The findings, consistent with the model of capillary action proposed for muscle by Renkin and Crone, are applicable to bone. There is no evidence that in normal bone the surface area available for exchange responds to an increase in bone blood flow.

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confidence: 99%

The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate

McCarthy

Hughes

1983

Calcif Tissue Int

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“…What has been observed is a peak in blood flow occurring between 7-14 days after fracture, followed by a prolonged remodeling period before a return to near pre-fracture flow rates. 2,3,4,5 These findings have correlated with innovatively designed studies investigating molecular angiogenic mediators and their relationship to endochondral fracture healing. The peak levels of these angiogenic mediators correlated with the peak rates of blood flow and were noted to coincide with the time of cartilage resorption, thus plausibly linking the two events.…”

Section: Introductionmentioning

confidence: 83%

Quantitative Analysis of Vascular Response after Mandibular Fracture Repair Using Microcomputed Tomography with Vessel Perfusion

Donneys

Tchanque-Fossuo

Farberg

et al. 2011

Plastic and Reconstructive Surgery

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Background Poor healing after mandibular fracture (Mfx) repair can be a devastating morbidity with significant clinical consequences. Elucidating the vascular response after Mfx may help determine potential areas for therapeutic interventions for non-unions. We performed Micro-Computed Tomography (μCT) imaging after vessel perfusion to ascertain objective measures of vascular networks. We hypothesize that despite the haversion based, highly cortical structure of the mandible, the vascular response after fracture healing will return to near normal levels soon after bony union, mirroring the results of endochondral, highly trabecular, long bones. Methods Sprague-Dawley rats (n=12) underwent mandibular osteotomy, and a 2.1 mm fixed gap was set. Animals were sacrificed at 40 days post surgery, and perfused with Microfil. Specimens underwent μCT analysis for stereological vascular metrics. Data was compared to non-fractured controls (n=5). Confidence Intervals (95%) and the independent samples t-test (p ≤ 0.05) were used to determine statistical differences. Results Quantitative measures for Mfx vs. Control revealed similarities in the following vascular metrics: Vessel Volume Fraction (0.028 vs. 0.032, CI = -0.027, 0.0169); Vessel Number (0.497 mm-1 vs. 0.472 mm-1, CI = -0.884, 0.975); Vessel Thickness (0.052 mm vs. 0.067 mm, CI = -0.037, 0.008) and Vessel Separation (2.344 mm vs. 2.081 mm, CI = -0.752, 1.278). Conclusions To our knowledge this is the first study utilizing μCT after perfusion to analyze vascular response following Mfx. Our findings establish quantitative similarities and qualitative differences in vascular response to fracture repair of the highly cortical mandible, when compared to the highly trabecular long bone.

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“…injection (De Graaf 1980). This explanation can be disputed, however as it has been demonstrated that uptake of 99mTc-MDP in the canine tibia was equivalent when the radiopharmaceutical was injected as a bolus as well as in the form of a constant infusion over a 30-min period (Hughes et al 1978). …”

Section: Decreased Renal Function and Its Effect On The Scintigraphicmentioning

confidence: 99%

Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure

1991

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In patients with renal bone disease skeletal and extra-skeletal abnormalities can be visualised using conventional bone scintigraphy. Some of these abnormalities are associated with characteristic scintigraphic appearances, which are reviewed in detail, and the possible mechanisms involved are discussed. Specific imaging with iodine 123 serum amyloid P component and iodine 131 flz-microglobulin is also discussed in the diagnosis of flz-microglobulin amyloidosis specific to patients on dialysis. In the light of available evidence, it appears that bone scintigraphy plays, so far, a limited role in the clinical evaluation of skeletal and extra-skeletal abnormalities in chronic renal failure. The potential role of bone scintigraphy in identifying patients with aluminlure-related bone disease needs to be investigated further, and in this respect special attention must be given to the problem of high soft-tissue activity associated with impaired renal function. Timing haemodialysis sessions before scintigraphic imaging deserves wider recognition as it reduces high soft-tissue activity, thereby allowing bone uptake to be assessed more accurately. Specific imaging of amyloidosis resulting from fi2-microglobulin deposition is a promising technique, but the relative value of the two proposed radiopharmaceuticals needs further clarification. Key words." Diphosphonates -Bone scintigraphy -Renal bone disease -fl2-Microglobulin amyloidosis -Extra-skeletal diphosphonate uptake Eur J Nucl Med (1991) 18:839--855

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The uptake by the canine tibia of the bone-scanning agent 99mTc-MDP before and after an osteotomy

Cited by 32 publications

References 11 publications

The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate

The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate

Quantitative Analysis of Vascular Response after Mandibular Fracture Repair Using Microcomputed Tomography with Vessel Perfusion

Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure

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