The uptake of Aspergillus ochraceus spores on diatomaceous particles and their use in the 11?-hydroxylation of progesterone

Broad, David; Foulkes, Joanne M.; Dunnill, P.

doi:10.1007/bf00138005

Cited by 14 publications

(3 citation statements)

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“…The results given herein for the spore loading of Celite R-630 compare favourably with those reported by Broad et al (1984). These authors observed that the saturation level for spores of Aspergillus ochraceus was 6-9 X 10' spores/g Celite 560.…”

Section: Industrial Significancementioning

confidence: 99%

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

et al. 1986

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Celite R‐630, a commercially available catalyst support, was used successfully in the batch and continuous production of Penicillin‐G by mycelial cells of Penicillium chrysogenum. As an extension of previous work, the productivity of a 1.2 L three phase fluidized bed bioreactor using the Celite support was compared directly with the same reactor in which cells had been immobilized inside a larger carrageenan support matrix. With Celite particles, maximum yields and specific reaction rates for continuous reactor runs were 0.11 g Pen‐G (K+)/g lactose and 0.05 mmol Pen‐G/h/g protein respectively. These results were similar to those obtained with carrageenan beads. However, on a reactor volume basis, Celite was five times more productive than carrageenan. Results are discussed in terms of the potential for using Celite in industrial bioreactor systems.

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Section: Industrial Significancementioning

confidence: 99%

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

et al. 1986

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“…This was demonstrated using Cunninghamella elegans in the li-hydroxylation of cortexolone (24) for corticosteroid production (11). Also reported is the use of fungal spores, instead of mycelium, and entrapment of these in the pores of particles of diatomaceous earth (filter aid Celite 560) illustrated by the li-hydroxylation of progesterone (25) (for corticosteroid production) by Aspergillus ochraceus (12).…”

Section: -Glucmentioning

confidence: 99%

Recent Developments in our Knowledge of Steroids¹

Hardman¹

1987

Planta Med

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Annually, the American Chemical Abstracts has some 3000 references to plant steroids or related compounds. This is a review of 34 selected papers mainly from the literature of [1984][1985]. Plant steroids as raw material for the pharmaceutical industry; tissue culture for steroids; horticultural trials of species for sapogenins; the in Vitro use of enzymes to increase the yield of sapogenins from plant material. New furostanol precursors of diosgenin; the cytotoxic activity of these and related compounds; their possible role in plant mineral metabolism. Microorganisms in the biotransformation of steroids; the exploitation of waste material as a source of sterols; the use of fungal spores on diatomaceous particles; the use of fungal protoplasts; hydrophobic resin as a product reservoir in such transformations. Brassinosteroids, their distribution as plant growth hormones; their microquantitative bioassay; physiological studies towards their use for enhancement of crop production; patented analogues obtained by partial synthesis. Ecdysones, their wide distribution in plants; their possible functions: effect on photosynthetic and respiratory rates; root protection against soil nematodes; dietary value in animal nutrition; their use in insect control. 29-Fluorophytosterols as pro-insecticides; fungal pregnanes as insecticides. Cardiac glycosides; ecological significance in plant-insect-bird relationships; new cardenolides, naturally occurring and those obtained by partial synthesis; the use of mesophyll cells in tissue culture; crossbreeding of Digitalis species. Steroidal alkaloids: reference to their annual review and to a steroidal antibiotic; the types of alkaloids now defineable in the Buxaceae and their chemotaxonomic significance for the new ones from the single genus family, Didymelaceae.

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“…The reaction probably proceeds as shown in Scheme 47. 206 A 2 1-(thiazol-4-y1)-compound (222) has been prepared from the corresponding 21-carboxylic ester.207 A steroid (223) in which a thiazole ring is fused to carbon atoms 1 and 2 has been prepared from 2-amino-oestrone methyl ether. 208 The ethoxycarbonylhydrazone of 17P-acetoxy-5a-androstan-3-one reacts with thionyl chloride to give the l-sulphinyl-[2,3dlthiadiazole (224).…”

mentioning

confidence: 99%

Steroids: reactions and partial syntheses

Elks¹

1986

Nat. Prod. Rep.

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The uptake of Aspergillus ochraceus spores on diatomaceous particles and their use in the 11?-hydroxylation of progesterone

Cited by 14 publications

References 10 publications

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

Recent Developments in our Knowledge of Steroids¹

Steroids: reactions and partial syntheses

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The uptake of Aspergillus ochraceus spores on diatomaceous particles and their use in the 11?-hydroxylation of progesterone

Cited by 14 publications

References 10 publications

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

Continuous production of penicillin‐g by penicillium chrysogenum cells immobilized on celite biocatalyst support particles

Recent Developments in our Knowledge of Steroids1

Steroids: reactions and partial syntheses

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Recent Developments in our Knowledge of Steroids¹