The Urinary Excretion of Oxalic Acid in Urolithiasis

Takasaki, Etsuji; Shimano, Eiichiro

doi:10.5980/jpnjurol1928.57.12_1267

Cited by 7 publications

(6 citation statements)

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“…This is evident from the vast number of methods which have been published on this topic in the last 10 years only to be discarded and replaced by others [13]. The lack of a totally reliable method for measuring urinary oxalate undoubtedly accounts for many of the ap parent discrepancies between those investigators who have found a significant increase in urinary oxalate amongst idiopathic stone-formers [12,14,32,34,38,42,43,56] and those who have not [27,46,49,51], Another reason is that the increases are relatively small in comparison with those found in patients with congenital or enteric hyperoxaluria, in which urinary oxalate is usually greater than 0.8 mmol/ day and where there is a very high risk of nephrocalcinosis, calcium oxalate stone disease and renal impairment [55]. This condition in which urinary oxalate excretion lies be tween the normal range and the congenital hyperoxaluric range may be termed 'mild* hyperoxaluria.…”

Section: Introductionmentioning

confidence: 90%

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Robertson

Peacock²

1980

Nephron

270

118

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Hypercalciuria is common in patients who form calcium oxalate urinary stones and is considered by many to be the cause ofthe disorder. This review shows that there is little relationship between either the rate of stone-formation or calcium oxalate crystalluria and the urinary excretion of calcium. There is, however, a strong relationship between these parameters and the urinary excretion of oxalate which is slightly, but significantly, elevated in stone-formers compared with normals. It is concluded that this mild degree of hyperoxaluria may be much more important than hypercalciuria in the genesis of calcium oxalate stones.

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Section: Introductionmentioning

confidence: 90%

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Robertson

Peacock²

1980

Nephron

270

118

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“…How ever, it is not clear at the present time to what extent mild hyperoxaluria can also be encountered in idiopathic stone formers; indeed, some investigators found a significant elevation o f oxalate excretion in these patients [1][2][3][4], whereas other investigators did not [5][6][7],…”

Section: Introductionmentioning

confidence: 93%

Influence of the Calcium Content of the Diet on the Incidence of Mild Hyperoxaluria in Idiopathic Renal Stone Formers

Jaeger¹,

Portmann²,

Jacquet³

et al. 1985

Am J Nephrol

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Urinary oxalate excretion was measured in 101 male idiopathic calcium (Ca) stone formers studied on 3 dietary conditions (free-choice, Ca-enriched, and low-Ca diet). The population consisted of 38 normocalciuric and 63 hypercalciuric patients. Mean oxalate excretion was similar in normocalciuric and in hypercalciuric patients, on free-choice as well as on Ca-enriched diet. In both conditions the incidence of hyperoxaluria ( ≥ 435 μmol/24 h) within each group of stone formers was also similar, ranging from 11 to 22%. On low-Ca diet, however, mean oxalate excretion increased significantly (p < 0.01) in hypercalciurics but not in normocalciurics; on this diet, the incidence of hyperoxaluria was particularly high in the hypercalciurics (33%), compared with the normocalciurics (13%). On low-Ca diet, oxalate excretion was positively correlated with the estimated degree of intestinal absorption of calcium (p=0.01). These results show that among idiopathic stone formers, mild hyperoxaluria is not a rare finding and that this disorder can be encountered in each group of patients; its incidence, however, is influenced by the calcium content of the diet. On a low-Ca diet, patients with intestinal Ca hyperabsorption are particularly prone to develop hyperoxaluria, an observation which leads to question the relevance of such a dietary advice unless oxalate intake is simultaneously reduced.

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“…The oxalate calculi always contain various amounts of calcium phos phate [4], The etiology of calcium oxalate-calcium phosphate calculus is problematic as well as obscure in many cases [12,15], In the current study, the author surveyed patients with calcium oxalate calculi mixed with various amounts of calcium phosphate (table II). Although there is some variation of percentage, the recurrence rate of stones with various mixture of calcium oxalate and calcium phosphate was about 40%.…”

Section: Discussionmentioning

confidence: 99%

An Observation on the Composition and Recurrence of Urinary Calculi

Takasaki¹

1975

Urol Int

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Seven hundred patients with 735 urinary calculi were studied for the compositions of calculi by infrared analysis and for stone recurrence. Of these 700 cases, 422 cases were possible to follow up, and 250 cases have had no further stone; 138 cases experienced recurring stones, and 34 cases had multiple stones. The length of follow-up period was 1–19 years averaging 8 years, 8 months. 41.2% of patients with calcium oxalate-calcium phosphate calculi had stones recurrently, and although there was some variation of recurrence rates for patients with various proportions of oxalate to phosphate in the calculi, it was impossible to predict the tendency of recurrence by these proportions. The stone recurrence was noted in 38.6% of patients with magnesium ammonium phosphate calculi, in 38.9% with mixed magnesium ammonium phosphate-calcium oxalate calculi, in 55.6% with uric acid calculi, and in 50% with cystine calculi.

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The Urinary Excretion of Oxalic Acid in Urolithiasis

Cited by 7 publications

References 0 publications

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Influence of the Calcium Content of the Diet on the Incidence of Mild Hyperoxaluria in Idiopathic Renal Stone Formers

An Observation on the Composition and Recurrence of Urinary Calculi

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