The Urinary Excretion of Protein, Non-Protein Nitrogen, Creatinine and Uric Acid in Ageing Male Rats

Everitt, Arthur V.

doi:10.1159/000210720

Cited by 25 publications

(11 citation statements)

References 22 publications

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“…The values for cc2u excretion, on the other hand, were con siderably more consistent. These differences probably reflect the fact that < X 2u is under hor monal control while the excretion of albumin and other plasma proteins (TUP) may be the consequence of the chronic glomerulonephrosis [7,8,13], Rats may exhibit considerable in dividual variation in developing glomerular lesions [9,18]; some may be more resistant than others. This is demonstrated by figure 2a, b showing the excretion of TUP and albu min for 3 representative rats.…”

Section: Resultsmentioning

confidence: 99%

“…The hepatic biosynthesis of this protein is under the control of androgens [4,5] and glucocorticoids [5], In the young male, the ot2u represents 25-30% of the total urinary pro tein (TUP) [6]. As the rat ages, the spontane ous degeneration of the kidney, called chronic or progressive glomerulonephrosis [7] leads to an increased excretion of TUP [8][9][10][11][12], In a study relating morphologic changes with age, Hirolcawa [13] demonstrated a fusion of podocytes and a glomerular thickening as early as 3 months of age. Since these changes are ac companied by an excretion of protein in the urine, it is thought that proteinuria is a con sequence of the renal changes.…”

Section: Introductionmentioning

confidence: 99%

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Age-Dependent Changes in the Excretion of Urinary Proteins by the Rat

Neuhaus¹,

Flory²

1978

Nephron

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The excretion of total urinary proteins (TUP) of rats beginning at weaning and extending to 12 months of age was correlated with the output of the sex-dependent α2u-globulin and albumin. At puberty, 40 days of age, the excretion of TUP corresponded to the output of α2u-globulin. At this age, α2u represented 30% of the total while albumin less than 10%. From 100 to 200 days of age, TUP remained constant while the excretion of albumin steadily increased. After 150–180 days of age, the concentrations of α2u and albumin in TUP were approximately equal. Thereafter, the excretion of albumin and TUP increased markedly whereas α2u excretion remained constant. At 373 days of age, albumin represented over 50–60% of the TUP while α2u was only 6–7%. Female rats which excrete little or no α2u exhibited a much lower level of proteinuria than the male during the first year. We suggest the existence of two phases of proteinuria in the male rat, namely, an early physiologic or α2u-globulinuric phase and a later albuminuric phase during which increasing quantities of plasma proteins, especially albumin, are lost.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-Dependent Changes in the Excretion of Urinary Proteins by the Rat

Neuhaus¹,

Flory²

1978

Nephron

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“…This correlates well with physiologic changes in the aging rat kidney. There is a progressive increase in glomerular basement membrane permeability to proteins, causing decreasing selectivity of urine protein excretion (7,28). The accumulation of mesangial material occurs later than the onset of glomerular permeability to proteins.…”

Section: Fig 7-hyalin Casts Within Distal Tubular Segments In Advancmentioning

confidence: 99%

Chronic Progressive Nephropathy in Aging Rats

Barthold

1979

Toxicol Pathol

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Chronic progressive nephropathy (CPN) i s a commonly encountered lesion i n aging laboratory rats. CPN has been given a variety of names, based upon i t s complex nature. It is a lesion that occurs primarily in albino strains and is influenced not only by genetics but also by sex, age, hormones, diet, and microflora, among other factors. Affected kidneys are enlarged, pale and finely indented. The lesion begins with progressive thickening of glomerular, Bowman's capsular and proximal tubular basement membranes. Mesangial matrix increases with deposition of IgM and, to a lesser extent, other serum components. Tubular atrophy and degenerative changes occur as the lesion progresses. The disease is manifested by increasingly non-selective proteinuria, consisting mainly of albumin. Serum chemical changes include elevations in a globulins and cholesterol and a decrease in albumin. Creatinine and urea remain unchanged until late in the course of CPN. Renal secondary hyperparathyroidism may occasionally be seen.

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“…One hundred and ten male rats of a non-inbred Wistar strain were housed in II cages in a small air-conditioned room (temperature 25 ±1° C, relative humidity 55±10%) and fed a pelleted diet as described previously (Everitt, 1958a).…”

Section: Methodsmentioning

confidence: 99%