The Urinary Tract Microbiome in Health and Disease

Aragón, Isabel M.; Herrera-Imbroda, Bernardo; Queipo‐Ortuño, María Isabel; Castillo, Elisabeth; Moral, Julia Sequeira-García Del; Gómez-Millán, Jaime; Yücel, Gözde; Lara, M. Fernanda

doi:10.1016/j.euf.2016.11.001

Cited by 232 publications

(223 citation statements)

References 76 publications

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“…A potential role for the microbiota is perhaps the most likely of all proposed aspects of urine quality according to current evidence, and this includes studies of microbiota in the urine of healthy patients . This evidence emphasizes a new perspective for the role of urine in bladder health: urine as a culture media.…”

Section: Microbiota Of the Bladder And Urine Qualitymentioning

confidence: 94%

Urine: Waste product or biologically active tissue?

2018

Neurourology and Urodynamics

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Section: Microbiota Of the Bladder And Urine Qualitymentioning

confidence: 94%

Urine: Waste product or biologically active tissue?

2018

Neurourology and Urodynamics

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“…While there are many other microbiomes present around the body, including those of the urinary system , the eye , the genitals and the skin , there is minimal evidence supporting a direct role for any of these microbiomes in PD, AD or MS. However, the urinary tract deserves mention.…”

Section: Other Microbiomesmentioning

confidence: 99%

Invited Review: From nose to gut – the role of the microbiome in neurological disease

Bell

Spencer

Yates

et al. 2018

Neuropathology Appl Neurobio

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Inflammation and neurodegeneration are key features of many chronic neurological diseases, yet the causative mechanisms underlying these processes are poorly understood. There has been mounting interest in the role of the human microbiome in modulating the inflammatory milieu of the central nervous system (CNS) in health and disease. To date, most research has focussed on a gut‐brain axis, with other mucosal surfaces being relatively neglected. We herein take the novel approach of comprehensively reviewing the roles of the microbiome across several key mucosal interfaces – the nose, mouth, lung and gut – in health and in Parkinson's disease (PD), Alzheimer's disease (AD) and multiple sclerosis (MS). This review systematically appraises the anatomical and microbiological landscape of each mucosal surface in health and disease before considering relevant mechanisms that may influence the initiation and progression of PD, AD and MS. The cumulative effects of dysbiosis from the nose to the gut may contribute significantly to neurological disease through a wide variety of mechanisms, including direct translocation of bacteria and their products, and modulation of systemic or CNS‐specific immunity. This remains an understudied and exciting area for future research and may lead to the development of therapeutic targets for chronic neurological disease.

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“…One promising area of study is the human urinary microbiome and its relation to kidney allograft function. Once felt to be a sterile body site, there is increasing knowledge of the composition of the urinary microbiome in healthy hosts . Alterations in the urinary microbiome have been explored in a variety of lower urinary tract disorders such as urinary incontinence, interstitial cystitis, urologic cancers, and chronic prostatitis, but little is yet known about urinary microbiome alterations in renal allograft dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

Muthusamy

Al‐Ghalith

et al. 2018

Clinical Transplantation

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Background We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD. Methods This case‐control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3 month post‐transplant baseline. Urine samples from patients with and without CAD were analyzed using 16S V4 bacterial ribosomal DNA sequences. Results Corynebacterium was more prevalent in female and male patients with CAD compared to non‐CAD female patients (P = 0.0005). A total 21 distinct Operational Taxonomic Unit (OTUs) were identified as significantly different when comparing CAD and non‐CAD patients using Kruskal‐Wallis (P < 0.01). A subset analysis of female patients with CAD compared to non‐CAD females identified similar differentially abundant OTUs, including the genera Corynebacterium and Staphylococcus (Kruskal‐Wallis; P = 0.01; P = 0.004, respectively). Male CAD vs female CAD analysis showed greater abundance of phylum Proteobacteria in males. Conclusion There were differences in the urinary microbiome when comparing female and male CAD patients with their female non‐CAD counterparts and these differences persisted in the subset analysis limited to female patients only.

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The Urinary Tract Microbiome in Health and Disease

Cited by 232 publications

References 76 publications

Urine: Waste product or biologically active tissue?

Urine: Waste product or biologically active tissue?

Invited Review: From nose to gut – the role of the microbiome in neurological disease

Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

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