The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile

Ajmal, Adil; Meskarzadeh, Ammon; Genina, Natalja; Hirschberg, Cosima; Boetker, Johan

doi:10.1208/s12249-019-1341-z

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…Excess casting formulation was removed using a spatula to provide the casted tablet with a smooth surface. The casted tablets were left to dry at room temperature for 24 h. Once dried, the printed cylinder was removed from each mould, and the tablets were detached using a scalpel [ 116 ].…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

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Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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“…Still in the medical field, but towards pharmaceutical applications, Ajmal et al [ 115 ] cast tablets of indomethacin in hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) formulation using commercial PLA molds 3D printed via FDM with four different designs (with a designed disintegration functionality, composed mainly of two parts: a detachable cylinder and base/lid, which would separate into up to six sections) established by CAD software. The PLA molds’ surfaces were lubricated with corn starch for easier tablet removal; after drying the tablets at room temperature for 24 h, the 3D-printed cylinder parts were removed and the tablets were detached from the molds (base/lid part) using a scalpel.…”

Section: Applications That Use 3d-printed Polymeric Moldsmentioning

confidence: 99%

The Use of Additive Manufacturing Techniques in the Development of Polymeric Molds: A Review

Pelin,

Sonmez,

Pelin

2024

Polymers

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The continuous growth of additive manufacturing in worldwide industrial and research fields is driven by its main feature which allows the customization of items according to the customers’ requirements and limitations. There is an expanding competitiveness in the product development sector as well as applicative research that serves special-use domains. Besides the direct use of additive manufacturing in the production of final products, 3D printing is a viable solution that can help manufacturers and researchers produce their support tooling devices (such as molds and dies) more efficiently, in terms of design complexity and flexibility, timeframe, costs, and material consumption reduction as well as functionality and quality enhancements. The compatibility of the features of 3D printing of molds with the requirements of low-volume production and individual-use customized items development makes this class of techniques extremely attractive to a multitude of areas. This review paper presents a synthesis of the use of 3D-printed polymeric molds in the main applications where molds exhibit a major role, from industrially oriented ones (injection, casting, thermoforming, vacuum forming, composite fabrication) to research or single-use oriented ones (tissue engineering, biomedicine, soft lithography), with an emphasis on the benefits of using 3D-printed polymeric molds, compared to traditional tooling.

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“…Ajmal et al [160] designed four different moulds using CAD software. 3D printed PLA tablets were designed with break lines to control disintegration into a defined number of sections.…”

Section: Insert Figurementioning

confidence: 99%