The use of 7-(2-bromoethoxy)coumarin for the quantitative fluorometric analysis of drug preparations containing a tertiary nitrogen atom

Abyshev, A. Z.; Klimov, V. G.; Крылов, С. С.; Семенов, Э. В.; Sidorova, I. P.

doi:10.1007/bf00766953

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…3. Other Heteropentacyclic Series (35)(36)(37)(38)(39)(40)(41). The lack of appreciable activity by 35A was probably due to the lack of aromatic or flat structural features of the oxazolinone ring.…”

Section: Preliminary Pharmacologymentioning

confidence: 99%

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

Bagley¹,

Thomas²,

Rudo³

et al. 1991

J. Med. Chem.

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A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (ED50 less than 1 mg/kg) superior to that of morphine. These studies revealed a pharmacological accommodation for many more structurally diverse and far bulkier aromatic ring systems than the corresponding components of the arylethyl groups of the prototypic methyl ester (carfentanil, 2) and methylene methyl ether (sufentanil, 3 and alfentanil, 4) 4-propionanilido analgesics. Compound 9A (methyl 1-[2-(1H-pyrazol-1-yl)-ethyl]-4-[(1-oxopropyl)phenylamino]-4- piperidinecarboxylate), which exhibited appreciable mu-opioid receptor affinity, was a more potent and short-acting analgesic, than alfentanil with less respiratory depression in the rat. On the other hand, the phthalimides 57A and 57B, which exhibited negligible affinity for opioid receptors associated with the mediation of nociceptive transmission (i.e., mu-, kappa-, and delta-subtypes), displayed analgesic efficacy in all antinociception tests. In addition, while 57B, compared to clinical opioids, showed a superior recovery of motor coordination after regaining of righting reflex from full anesthetic doses in the rat rotorod test, 57A showed significantly less depression of cardiovascular function at supraanalgesic doses in the isoflurane-anesthetized rat.

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Section: Preliminary Pharmacologymentioning

confidence: 99%

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

Bagley¹,

Thomas²,

Rudo³

et al. 1991

J. Med. Chem.

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“…It was reported that 7-(2-bromoethoxy)coumarin can be used as a fluorescent label for the quantitative fluorimetric analysis of drugs with molecules containing tertiary nitrogen atom [89]. Fluorescent microscopy can be used for the localization and quantitative determination of hydroxylated coumarin derivatives playing the role of photoprotectors in Dasycladis vermicularis (Scopoli) Krasser algae [5].…”

Section: Methods Of Analysis Of Coumarinsmentioning

confidence: 99%

Natural coumarins: Methods of isolation and analysis

Lozhkin

Sakanyan

2006

Pharm Chem J

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With a view to optimizing of the quality control of sweetclover herbs and related preparations containing coumarins among the active substances, methods for the isolation and analysis of compounds of this class -in particular, coumarin and furocoumarin -are reviewed. The group of possible analytical methods includes gravimetric, titrimetric, photocolorimetric, and polarographic analysis, and the more recently developed spectroscopic (UV and IR), fluorimetric, and chromatographic (GC and HPLC) techniques.Psoralen: R 1 = H, R 2 = H; Xanthotoxin: R 1 = H, R 2 = OCH 3 ;Bergapten: R 1 = OCH 3 , R 2 = H; Isopimpinellin: R 1 = OCH 3 , R 2 = OCH 3 .

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The use of 7-(2-bromoethoxy)coumarin for the quantitative fluorometric analysis of drug preparations containing a tertiary nitrogen atom

Cited by 2 publications

References 3 publications

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

Natural coumarins: Methods of isolation and analysis

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