In this study, we aimed to retrospectively evaluate the complications of ankle fusion for treating late sequelae of ankle injuries (LS-AI). We retrospectively analyzed patients with LS-AI who were treated with ankle fusion in our hospital between January 1997 and June 2012; we summarized the surgical methods, internal fixation selection, follow-up time, preoperative and follow-up-end American Orthopaedic Foot & Ankle Society (AOFAS) score, and complications. A total of 48 patients were analyzed, including 14 patients with open tibial and fibular fracture-induced lower limb compartment syndrome sequelae, 33 patients with ankle and Pilon fracture-caused traumatic ankle arthritis, and 1 patient with ankle amputation injury. The average follow-up time was 49.1 months. The incidence rate of complications was 29.17 %, including 4 cases of wound infection, 3 cases of delayed union, 1 case of nonunion, 2 cases of malunion, 2 cases of nerve injury, and 2 cases of internal fixation fracture. The average preoperative AOFAS score was 44.3 points, and the average postoperative score was 81.2 points (P<0.05). Ankle fusion is still the most effective method for treating late complications of ankle injuries.