The Use of Anthropometric Measurements of Obesity in Prediction of Microvascular Complications in Obese Type 2 Diabetic Patients

Bulum, Tomislav; Blaslov, Kristina; Duvnjak, Lea

doi:10.20471/acc.2016.55.02.06

Cited by 16 publications

(14 citation statements)

References 39 publications

(51 reference statements)

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“…Acute microangiopathy is also known as acute systemic microangiopathy, such as shock and DIC [9]; however, the most typical diabetes-induced microangiopathy is chronic microangiopathy [10]. Numerous studies have found that endothelial cells play key roles in the pathogenesis of diabetic microangiopathy, and significant changes occur in the cell structure and function [11]. In diabetic retinopathy and glomerular lesions, vascular endothelial cells are damaged, which destroy the blood-retinal and blood-glomerular barriers, thickens the stroma, and induces fibrotic changes, eventually leading to retinal detachment or glomerular barrier dysfunction [12,13].…”

Section: Introductionmentioning

confidence: 99%

Role of Natural Killer T (NKT) Cells in Type II Diabetes-Induced Vascular Injuries

Gao

Dong

et al. 2018

Med Sci Monit

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BackgroundThis study investigated the distribution and features of natural killer T (NKT) cells in the peripheral blood of diabetic patients, and their regulatory roles on vascular endothelial cells.Material/MethodsPeripheral lymphocytes were isolated from diabetic patients. NKT cell distribution, proportion, and surface and intracellular markers were detected with flow cytometry. Peripheral blood-derived NKT cells were isolated and co-cultured with human umbilical vein endothelial cells (HUVECs). Proliferation and migration of HUVECs were assessed with the CCK-8 assay and the Transwell chamber assay.ResultsThe ratios of CD3-CD56+ NK and CD3+CD56+ NKT cells in the peripheral blood of patients with type II diabetes were significantly elevated. The expression levels of NKp30, NKG2D, and NKp44 on the surface were increased in the CD3+CD56+ NKT cells, while the expression levels of NKG2A and 158b were significantly downregulated. The expression level of granzymes in the peripheral blood-derived NKT cells were not changed in patients with type II diabetes, but the expression levels of IFNγ and IL-4 were significantly increased. However, after co-culture with NKT cells derived from the peripheral blood of diabetic patients, the proliferation and migration of HUVECs were significantly inhibited, and was restored by treatment with IL-4 antibody. In addition, the IL-4 stimulus inhibited the proliferation and migration of HUVECs.ConclusionsPeripheral blood NKT cells are increased and activated in diabetes. NKT cells inhibit the proliferation and migration of HUVECs by secreting IL-4, thereby inducing vascular injuries.

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Section: Introductionmentioning

confidence: 99%

Role of Natural Killer T (NKT) Cells in Type II Diabetes-Induced Vascular Injuries

Gao

Dong

et al. 2018

Med Sci Monit

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“…Th e results on the mean waist circumference in patients (100.43±13.88 cm for female and 105.07±8.98 cm for male patients) were higher than the reference data from the literature, which are 92±13 cm 22 and 88±12 cm 23 . Th e greater the waist circumference, the greater is the risk of chronic disease development and cardiovascular events, with the accumulation of fat around the waist being a predictor of NAFLD development [25][26][27] . Th e results on BMI in this research are closest to the results obtained in Italy 22 , while the mean waist circumference was >10% greater than in the same group of Italian subjects.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status and Nutrition Quality in Patients with Non-Alcoholic Fatty Liver Disease

Bender

Nutrizio

Jošić³

et al. 2017

ACC

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Non-alcoholic fatty liver disease (NAFLD) is becoming a major health burden with increasing prevalence worldwide due to its close association with the epidemic of obesity. Currently there is no standardized pharmacological treatment, and the only proven effective therapeutic strategy is lifestyle modification, therefore it is important to determine the potential dietary targets for the prevention and treatment of NAFLD. We assessed nutritional status in 30 patients diagnosed with NAFLD using anthropometric parameters, hand grip strength, and lifestyle and dietetic parameters (physical activity, NRS2002 form and three-day food diary). The mean body mass index was 29.62±4.61 kg/m2, yielding 86.67% of obese or overweight patients. Physical activity results indicat-ed poorly active subjects. Excessive energy intake was recorded in 27.78% of patients. The mean in-take of macronutrients was as follows: 15.5% of proteins, 42.3% of carbohydrates and 42.2% of fat, with -deficient micronutrient intake of calcium, magnesium, iron, zinc, and vitamins A, B1 and B2. The -results showed that the quality of nutrition in study subjects was not accordant to current rec-ommendations and that they consumed a high proportion of fat, especially saturated fatty acids, along with low micronutrient intake. The results obtained might point to the importance of unbalanced diet as a contributing factor in NAFLD development.

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“…Insulin was measured by chemiluminescent immunometric assay (Immulite 2000, Siemens, Munich, Germany). Homeostasis assessment of insulin resistance (HOMA-IR) and eGFR were calculated as described in detail elsewhere ( 14 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular Risk Assessed by Reynolds Risk Score in Relation to Waist Circumference in Apparently Healthy Middle-Aged Population in Montenegro

Klisić

Kavarić

Bjelaković

et al. 2018

ACC

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SUMMARY – Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2±6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (χ 2 =45.9, p<0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p<0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p<0.001, respectively), and creatinine, but lower eGFR and HDL-c (p<0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (β=0.194, p=0.006; β=0.286, p=0.001; β=0.267, p=0.001; and β=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.

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The Use of Anthropometric Measurements of Obesity in Prediction of Microvascular Complications in Obese Type 2 Diabetic Patients

Cited by 16 publications

References 39 publications

Role of Natural Killer T (NKT) Cells in Type II Diabetes-Induced Vascular Injuries

Role of Natural Killer T (NKT) Cells in Type II Diabetes-Induced Vascular Injuries

Nutritional Status and Nutrition Quality in Patients with Non-Alcoholic Fatty Liver Disease

Cardiovascular Risk Assessed by Reynolds Risk Score in Relation to Waist Circumference in Apparently Healthy Middle-Aged Population in Montenegro

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