The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery

Man, Daniel; Plosker, Harvey; Winland-Brown, Jill E.

doi:10.1097/00006534-200101000-00037

Cited by 370 publications

(174 citation statements)

References 11 publications

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“…Blood and PPP contained the highest amount of FBG (423 and 440 mg/ dl, respectively), while aPRP contained only 234 mg/dl FBG. The values of FBG that were quantified in blood, aPRP, and PPP were expected, and are consistent with previously published data [44,54,55]. The reason behind why 200 mg/ml PRGF contained less amounts of FBG than 100 mg/ml PRGF is not completely understood, and will need to be investigated further in future studies.…”

Section: Fluorescent Based Assaysupporting

confidence: 90%

The Creation of Electrospun Nanofibers from Platelet Rich Plasma

Wolfe¹,

Sell²,

Ericksen³

et al. 2011

J Tissue Sci Eng

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Activated platelet rich plasma (a PRP) contains supra physiologic amounts of autologous growth factors and cytokines known to enhance wound healing and tissue regeneration. Here we report the first results of electro spinning nanofibers from a PRP to create fibrous scaffolds that could be used for various tissue engineering applications. Human platelet rich plasma (PRP) was created, activated by a freeze-thaw-freeze process, and lyophilized to form a powdered preparation rich in growth factors (PRGF). It was dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) at different concentrations to form fibers with average diameters of 0.3 -3.6 µm. A sustained release of protein from the PRGF scaffolds was demonstrated up to 35 days, and cell interactions with the PRGF scaffolds confirmed cell infiltration after just 3 days. As electro spinning is a simple process, and PRGF contains naturally occurring growth factors in physiologic ratios, creating nanofibrous structures from PRGF has the potential to be beneficial for a variety of tissue engineering applications.

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Section: Fluorescent Based Assaysupporting

confidence: 90%

The Creation of Electrospun Nanofibers from Platelet Rich Plasma

Wolfe¹,

Sell²,

Ericksen³

et al. 2011

J Tissue Sci Eng

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“…Os achados deste ensaio são semelhantes aos de Liu et al (2002), que mostraram aumento da produção de macrófagos, proliferação de fibroblastos e colágeno são proporcionais ao aumento da concentração plaquetária no PRP. Bhanot et al (2002) e Man et al (2001), também relataram que o PRP aumenta a taxa de produção de colágeno, angiogênese, proliferação de fibroblastos e síntese de matriz extracelular, melhorando a reparação de modo geral.…”

Section: Resultsunclassified

Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus)

et al. 2016

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Wounds of large tracts with loss of tissue viability and delayed healing by secondary intention are cases where it is necessary the use of reconstructive surgical techniques. The platelet rich plasma (PRP) is a product with a higher platelet concentration, adjuvant in the healing process of reconstructive surgeries, assisting in the processes of hemostasis and stimulation of angiogenesis. Thus, a study was devised to assess the efficacy of the gel produced from the platelet rich plasma (PRP) in the forward axial flaps thoracodorsal pattern in rabbits to evaluate the ability to promote the integration of the flap the recipient bed. We used 30 white rabbits New Zealand, separated into two groups of 15 animals, comprising the platelet rich plasma groups (GPRP), in which we used the gel before the synthesis of the surgical wound , and control (CG), in which only saline was used. To obtain the PRP, the blood was collected from the animals, was determined and the platelet count before preparation of the gel. At the beginning and end of the experiment the animals were weighed for analysis of average weight gain. After surgery began macroscopic in the 3rd, 7th and 14th day reviews, and we assessed the presence or absence of exudate, skin integrity, edema, redness and necrosis. After this step, yielded the material for the manufacture of surgical wound, followed by microscopic histological slides. We evaluated vascular proliferation, presence of polymorphonuclear and mononuclear cells, fibroblast proliferation, collagen deposition, reepithelialization and hemorrhage. The data were subjected to statistical analysis (Student t test, t paired, and Kruskal Wallis test, and p<0.05). The average weight gain was not significant between the groups; platelet concentration in the final sample of PRP was significantly higher when compared with the original; exudate and necrosis were significantly higher in the control group compared to PRP group, vascular proliferation and reepithelialization were significantly greater in PRP group, whereas the presence of mononuclear cells, polymorphonuclear cells, proliferation of fibroblasts, collagen and hemorrhage were not significant between groups. Obtained on the third day, as the difference significantly greater exudate variable in the control group compared to the PRP group; on 1 Recebido em 14 de fevereiro de 2015.Aceito para publicação em 22 de setembro de 2015.

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“…PRP is the natural resource of growth factors and a number of cytokines. Platelets realize the release of growth factors from α-granules by activating after the release of calcium or thrombin 27,28 . There are studies related to the integration of these growth factors showing variety in order to imitate the natural environment of tissue formation, especially in tissue engineering research.…”

Section: Discussionmentioning

confidence: 99%