The Use of Bacteriophages in Animal Health and Food Protection

Kosznik-Kwaśnicka, Katarzyna; Topka, Gracja; Dydecka, Aleksandra; Necel, Agnieszka; Nejman-Faleńczyk, Bożena; Bloch, Sylwia; Węgrzyn, Grzegorz; Węgrzyn, Alicja

doi:10.1007/978-3-030-26736-0_9

Cited by 4 publications

(5 citation statements)

References 309 publications

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“…Like pre- and probiotics, synbiotics reduce diarrhea, increase digestibility and daily weight gain, and promote beneficial bacterial strains, such as Lactobacillus and Bifidobacterium strains, leading to a more balanced gut microbiota [ 179 ]. The presence of prebiotics in the mixture assists probiotics in overcoming potential survival challenges [ 180 ]. However, the majority of synbiotics used in animal feed have insufficient probiotic/prebiotic mixing ratios, and appropriate controls would need to be used in experiments for the development of symbiotic-supplemented animal feed [ 181 ].…”

Section: Alternatives To Antibiotics As Growth Promotersmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.

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Section: Alternatives To Antibiotics As Growth Promotersmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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“…An exception to the suggestion that multiple or continuous dosing might always be assumed to be necessary can be found in the treatment of non-human subjects such as industrially raised chickens (Kosznik-Kwaśnicka et al, 2019).…”

Section: Multiple or Continuous Dosingmentioning

confidence: 99%

“…In this case limitations of convenience or of economic feasibility can be severe, resulting in greater impetus to design treatments in which a single dose is sufficient (Carvalho et al, 2010). Under those circumstances, dosing with higher phage titres also may be more feasible from a regulatory or safety perspective (Sulakvelidze and Pasternack, 2010;Kosznik-Kwaśnicka et al, 2019). Also, it is important to keep in mind that single doses can be effective even in the clinic (Wright et al, 2009;, and potentially more effective than multiple dosing with too low phage titres (Jault et al, 2019).…”

Section: Multiple or Continuous Dosingmentioning

confidence: 99%

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2021

Current Issues in Molecular Biology

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Pharmacology can be differentiated into two key aspects, pharmacodynamics and pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while pharmacokinetics describes the body's impact on a drug. Another way of understanding these terms is that pharmacodynamics is a description of both the positive and negative consequences of drugs attaining certain concentrations in the body while pharmacokinetics is concerned with our ability to reach and then sustain those concentrations. Unlike the drugs for which these concepts were developed, including antibiotics, the bacteriophages (or 'phages') that we consider here are not chemotherapeutics but instead are the viruses of bacteria. Here we review the pharmacology of these viruses, particularly as they can be employed to combat bacterial infections (phage therapy). Overall, an improved pharmacological understanding of phage therapy should allow for more informed development of phages as antibacterial 'drugs', allow for more rational post hoc debugging of phage therapy experiments, and encourage improved design of phage therapy protocols. Contrasting with antibiotics, however, phages as viruses impact individual bacterial cells as single virions rather than as swarms of molecules, and while they are killing bacteria, caister.com/cimb 81 Curr. Issues Mol. Biol. Vol. 40bacteriophages also can amplify phage numbers, in situ. Explorations of phage therapy pharmacology consequently can often be informed as well by basic principles of the ecological interactions between phages and bacteria as by study of the pharmacology of drugs. Bacteriophages in phage therapy thus can display somewhat unique as well as more traditional pharmacological aspects.

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“…Cumulative mortality rates in young fish can reach 75% in a matter of weeks [ 7 ]. Phage treatment as a natural remedy against bacterial infections in the food industry has been reported in numerous peer-reviewed articles and books within the past decades [ 22 , 23 , 24 , 25 , 26 , 27 ], with the first work published as early as in the 1930s [ 28 ]. Phage products intended for use in the food industry are already commercially available and have been proven to be useful in protecting a vast range of food and crops [ 24 , 29 , 30 , 31 , 32 ].…”

Section: Bacterial Disease and Spoilage In The Fish And Seafood Inmentioning

confidence: 99%

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

2020

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Facing antibiotic resistance has provoked a continuously growing focus on phage therapy. Although the greatest emphasis has always been placed on phage treatment in humans, behind phage application lies a complex approach that can be usefully adopted by the food industry, from hatcheries and croplands to ready-to-eat products. Such diverse businesses require an efficient method for combating highly pathogenic bacteria since antibiotic resistance concerns every aspect of human life. Despite the vast abundance of phages on Earth, the aquatic environment has been considered their most natural habitat. Water favors multidirectional Brownian motion and increases the possibility of contact between phage particles and their bacterial hosts. As the global production of aquatic organisms has rapidly grown over the past decades, phage treatment of bacterial infections seems to be an obvious and promising solution in this market sector. Pathogenic bacteria, such as Aeromonas and Vibrio, have already proved to be responsible for mass mortalities in aquatic systems, resulting in economic losses. The main objective of this work is to summarize, from a scientific and industry perspective, the recent data regarding phage application in the form of targeted probiotics and therapeutic agents in aquaculture niches.

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The Use of Bacteriophages in Animal Health and Food Protection

Cited by 4 publications

References 309 publications

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Phage Therapy: The Pharmacology of Antibacterial Viruses

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

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