The Use of Bisphosphonate-Hydroxyapatite Composite in Bone Augmentation

Doca, Sorin Cristian; Vlase, Gabriela; Vlase, Titus; Găluşcan, Atena; Bălean, Octavia; Negru, Daniel; Jumanca, Daniela

doi:10.37358/rc.20.6.8166

Cited by 4 publications

(4 citation statements)

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“…2-4), the bands near 1037 and (988, 602) cm -1 attributed to {n as (P-O) and n s (P-O)} and {n as (P-C-P) and n s (P-C-P)} stretching vibrations, respectively, were shifted to lower wavenumber. This feature indicates the participation of P-O in H-bond formation with HA (Neamtu et al 2017;Doca et al 2020). The bands observed in 3537-3487 cm −1 region, are due to n(OH) stretching of (P-OH, C-OH groups) and hydrated water (Mir et al 2012).…”

Section: Resultsmentioning

confidence: 82%

Hydroxyapatite Based Composites for Bone Regeneration

Mostafa

Ismail

Mohammed

et al. 2022

Preprint

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Aim of study: Preparation and characterization of the new nanocomposite, magneto-hydroxyapatite-alendronate (mag-HA-Ald np), for bone tissue scaffolds formation. Material and methods Iron oxide nanoparticles (Fe3O4 np) were added to aqueous solutions of Ca(NO3)2.4H2O and (NH4)2HPO4 for obtaining mag-HA np. The target nanocomposites, mag-HA-Ald np, were synthesized by using aqueous solution of alendronate (Ald), with different ratios. The structure of the prepared nanocomposites were investigated based on spectral (FTIR, XRD, SEM) and EDX analysis. The cytotoxicity of the nanocomposites were performed using MTT assay, to detect the effect of magnetic field application on the cell viability; two culture methods were applied (with and without magnetic field exposure). Results The spectral, FTIR, XRD, SEM as well as EDX measurements confirmed the synthesis of nanocomposite, magneto-hydroxyapatite-alendronate (mag-HA-Ald np) with different ratios. MTT assay results suggested the positive correlation between Ald and iron oxide content with cell viability. In addition, Magnetic field application significantly decreases the cell viability in all groups in comparison to non- magnetic field application.

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Section: Resultsmentioning

confidence: 82%

Hydroxyapatite Based Composites for Bone Regeneration

Mostafa

Ismail

Mohammed

et al. 2022

Preprint

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“…The pore size distributions of HAp-SB presented in Fig. 8b were calculated with the Barret− Joyner− Halenda (BJH) 16 model from their desorption data. The average pore diameter and total…”

Section: Resultsmentioning

confidence: 99%

“…Hydroxyapatite (HAp, Ca/P ratio equal to 1.67. ), 1 is a well-known biomaterial and is the main inorganic component of the calcified tissues [16]. Furthermore, besides the special biological properties, HAp possesses good adsorption properties.…”

Section: Introductionmentioning

confidence: 99%