IntroductionMesoamerica is a cultural and historical region were several important civilizations developed, such as Toltec, Zapotec, Maya and Aztec. Guatemala is a diverse country, pluricultural and multilingual, with a profoundly syncretic culture as a heritage of Maya and Spanish cultures. It is a region of high diversity, which complement the biological richness with a profound value for this local biodiversity by its inhabitants with an integral vision, including diverse applications such as flavors, aromas, spices and condiments, dyes and colorants; food (grains, oilseeds, fruits, herbs), and medicinal plants, herbals and cosmetics. This minireview paper deals with the historical usage of plants for hair and skin care, and the recent investigations on antioxidant, solar protection and tyrosinase inhibition potential for skin clearing of native species from the Mesoamerican biodiversity.