The use of cerium nitrate-silver sulphadiazine as a topical burns dressing

Ross, David; Phipps, A.; Clarke, J.A.

doi:10.1016/0007-1226(93)90110-w

Cited by 57 publications

(25 citation statements)

References 8 publications

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“…Silver coated dressings are used extensively in wound management, particularly burn wound 11 , chronic leg ulcers and traumatic injuries 12,13 . The nanoscale silver will play important roles in understanding the ability to manipulate biological process which will be the central theme to present biomedical & biological issues that need a nanoscience of nanotechnology approach.…”

Section: Issn: 0975-8232mentioning

confidence: 99%

Untitled

2012

IJPSR

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Bionanotechnology has emerged up as integration between biotechnology and nanotechnology for developing biosynthetic and environmental friendly technology for synthesis of nano materials. Silver has been known to have effective bactericidal properties for centuries. Nowadays, silver based topical dressings have been widely used as a treatment for infection in burns, open wounds, and chronic ulcer. As the pathogenic organisms are getting evolved day by day due to mutation and gaining antibiotic resistance, an important industrial sector of nanosciene deals with the preparation and study of nanoparticles in antibacterial clothings, burn ointments and coating for medical device. The size of nanomaterials is much smaller than that of most biological molecules and structures, therefore nanomaterials can be useful in both in vivo and in vitro biomedical research application. The purpose of the study is to synthesis and characterizes the fungal silver nanoparticles using F.oxysporum. Further investigation of the shape and size of fungal nanoparticle was done by X-ray diffraction and Scanning electron microscopic studies. A silver nanoparticle at different concentration was assessed for its antibacterial effect, against various bacteria.Further Silver based topical dressing incorporated with fungal nanoparticle was prepared and integrated into cotton band aid gauze. This study revealed the enhancement of the synthesis of silver nanoparticles by the reduction of aqueous silver ions by simultaneous release of extracellular metabolites from the culture of F. oxysporum. It also focuses on the potential application of silver nanoparticles in the medical field as a topical dressing against various wound pathogens.

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Section: Issn: 0975-8232mentioning

confidence: 99%

Untitled

2012

IJPSR

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“…In instances such as these, Flammacerium has been shown to be hugely effective in diminishing the immunosuppressive effects of the in situ burn eschar (Figure 1). Experimentally it has been shown to bind and denature the LPC within the eschar (26) and clinical studies have demonstrated significant improvements in survival following CN-SSD treatment of major burns (27,13). It is likely that this represents the predominant mechanism by which cerium improves outcome after major burn injury.…”

Section: Flammaceriummentioning

confidence: 99%

“…This barrier also maintains a moist environment beneath the eschar, previously shown to improve the rates of wound healing (11,12). The eschar usually lifts by about three weeks leaving a non-infected bed free of granulations that will readily accept a split skin graft (13).…”

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confidence: 99%

Plastic Surgery

Heppell

2004

J R Army Med Corps

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The range of casualties treated by the Defence Medical Services in the recent Gulf conflict has reaffirmed the important role of plastic surgery within the military. This review seeks to highlight some areas of recent innovation and improvement within the realms of plastic surgery generally, of which some, such as the introduction of Flammacerium and the availability of skin substitutes, have direct military relevance.

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“…Nanoparticles has a significant potential for a wide range of biological applications such as antifungal agents, antibacterial agents for antibiotic resistant bacteria, preventing infections, healing wounds and anti-inflammatory [2]. The new technology of impregnation of silver nanoparticles are now commercially available and silver coated dressings are used extensively for wound management, particularly in burn wounds [3,4], Chronic leg ulcers [5], diabetic wounds [6] and traumatic injuries. The dressing component are also varies, as nylon, mesh, and hydrocolloid or methyl cellulose.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial silver nanoparticle induces organ deformities in the developing Zebrafish (Danio rerio) embryos

Kannan¹,

Jerley²,

Ranjani³

et al. 2011

JBiSE

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Silver Nanoparticles were synthesized by Escherichia coli using Silver nitrate in the growth medium and characterized in X-Ray Diffraction, UVVis Spectrophotometer and Scanning Electron Microscope. They exhibited antimicrobial activity against human pathogens except Escherichia Coli. Nanoparticles were impregnated in yarn and analyzed for their inhibition in the broth culture. The Minimal Inhibitory Concentratio was calculated for the human pathogens in Microtitre plate. The toxicity assessment of the nanoparticles in the embryonic Zebrafish showed many organogensis deformities like cardiac malformations, eye and head edema, tail and trunk flexure were observed in the organ system of the developing embryos for 1 to 5 day post fertilization in different concentrations of Ag Nanoparticles. The Organogenesis disruptive effects were found in 14 -20 ng/ml of silver nanoparticles but the inhibition was found in 4-10ng/ml for the pathogens in vitro and 10ng/ml in embryos. Nevertheless, in Cardiac assay, the Heart Beat rates were calculated as 42 -45 for 15 Sec in the concentrations ranging from 10 -20 ng/ml of Silver nanoparticles. The blood flows, rhythmicity, contractility of heart beat rates were observed normal. The Mean value of blood Cell counting did not showed any notable effects in the Nanoparticle treated Zebrafish embryos and control. The LC50 value for the Biosynthesized nanoparticle was at 22 ng/ml in all the developmental stages of the embryos. Our results shows silver nanoparticles disrupts the normal organogenesis during development and further detailed studies are needed to prove silver nanopartcles are an antimicrobial agent for use in humans.

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The use of cerium nitrate-silver sulphadiazine as a topical burns dressing

Cited by 57 publications

References 8 publications

Untitled

Untitled

Plastic Surgery

Antimicrobial silver nanoparticle induces organ deformities in the developing Zebrafish (Danio rerio) embryos

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