The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood

Chisolm, J. Julian

doi:10.1016/s0022-3476(68)80036-8

Cited by 223 publications

(84 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this figure, two curves are overlapped by proving the inability of developing a ternary complex between Pb(II) and the ligand combination used. Being a borderline metal, lead is presumed to have strong interactions with the donor atoms S and N preferably and as well as with O (Das, 1990;Chisolm, 1968). Thus, one can expect considerable interactions between Pb(II) and any molecule containing at least one of the above mentioned donor atoms.…”

Section: Resultsmentioning

confidence: 99%

Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Chandrathilaka

Hettiarachchi

2017

Ceylon J. Sci.

View full text Add to dashboard Cite

Lead is the most distributed toxic metal in the world and chelation therapy is a remedy for removing it from the body, if a person is intoxicated. Stability constants of both binary and mixed ligand complexes of Pb(II) with salicylic acid, ascorbic acid, vitamin B 1 (thiamine), vitamin B 3 (niacin) and Na 2 EDTA were potentiometrically studied, in aqueous media at the temperature of 37.0 ± 0.2 ⁰ C and the ionic strength of 0.15 mol dm -3 in order to identify better mixed ligand systems suitable for chelation therapy of lead. Both metal-ligand and proton-ligand formation constants were calculated using IrvingRossotti equations. The Formation of ternary complexes was further confirmed theoretically by plotting composite curves. Δ log K values calculated revealed that all mixed complexes were more stable than the complexes of corresponding binary systems. EDTA-Vitamin B 1 and EDTA-Ascorbic mixed complexes with Pb(II) disclosed very high stability constants, which were two times greater than that of EDTA binary complex. Vitamin B 1 revealed a remarkably high ability in forming mixed ligand complexes with all other four ligands. Results of this work clearly indicate that (EDTA-Vitamin B 1 ), (EDTA-Ascorbic), (Vitamin B 1 -Ascorbic), (Vitamin B 1 -Salicylic) and (Vitamin B 1 -Vitamin B 3 ) combinations can be used for detoxification of lead more effectively using dietary ligands.

show abstract

Section: Resultsmentioning

confidence: 99%

Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Chandrathilaka

Hettiarachchi

2017

Ceylon J. Sci.

View full text Add to dashboard Cite

show abstract

“…Although CSF penetration of CaNa 2 EDTA is beneficial, there is an initial risk of redistribution of lead into the CSF with CaNa 2 EDTA. Therefore, CaNa 2 EDTA administration is often preceded by a dose of intramuscular BAL to limit this redistribution into the CNS [6]. BAL and CaNa 2 EDTA are given intramuscularly and intravenously, respectively, due to poor oral absorption and thus have been the preferred agents in encephalopathic patients who may be at risk for aspiration with oral medication use.…”

Section: Discussionmentioning

confidence: 99%

Management of Lead Encephalopathy with DMSA After Exposure to Lead-Contaminated Moonshine

Arnold

Morgan

2015

J. Med. Toxicol.

View full text Add to dashboard Cite

Background Lead encephalopathy is a severe manifestation of lead poisoning that can present with altered mental status and seizures and has been associated with illicit moonshine consumption. Lead encephalopathy has traditionally been treated using dimercaprol (British antiLewisite, BAL) and calcium disodium ethylenediaminetetraacetic acid (CaNa 2 EDTA). Case Report We describe a patient with lead encephalopathy related to lead-contaminated moonshine consumption, who was treated using dimercaptosuccinic acid (DMSA) due to a national shortage of CaNa 2 EDTA. A 66-year-old woman presented to a hospital with headache, irritability, and altered mental status. On hospital day 16, she was found to have a whole blood lead concentration of 148.2 μg/dL and a 24-h urine lead concentration of 232 μg/day. Due to a national shortage of CaNa 2 EDTA, the patient was given one dose of BAL and then started on DMSA via nasogastric tube. She dramatically improved over 4 days and was subsequently transitioned to oral DMSA and outpatient treatment. One day prior to discharge, her whole blood lead concentration was 47.2 μg/dL and her mental status was normal. DMSA was used in lieu of CaNa 2 EDTA to treat the patient with lead encephalopathy. The patient subsequently experienced clinical improvement and declining whole blood level concentrations. Conclusion Further prospective studies are needed to compare the efficacy of DMSA versus CaNa 2 EDTA in patients with lead encephalopathy.

show abstract

“…These chelating agents either individually or in combination have been proven to be effective in promoting the excretion of toxic metal ions from the body organs (Chisolm, 1978;Batton et al, 1981;Tandon and Flora, 1989;Ghazaly, 1991;Misra et al, 2008). The efficacy of the chelating agents to remove metals from the biological system depends on their ability to form stable complexes with the toxic metal ions and to enhance their excretion from the body without affecting the levels of essential trace elements (Misra et al, 2008).The high affinity of EDTA for copper, zinc and iron may be due to the high stability constants of copper, zinc and iron-EDTA complexes in solution.…”

Section: Discussionmentioning

confidence: 99%

Physiological studies of some chelating agents in accumulation of some heavy metals in Tilapa florida

Ohaida

2015

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

The three chelating agents. EDTA. Thiamin and Ascorbic acid were tested for balance and tissue distribution of four essential trace elements, copper. Zinc, iron and manganese, blood, liver kidney and muscle in Tilapia florida. Essential trace element balance was less affected by thiamin administration. Thiamin produced minimum alterations in the tissue levels of essential trace elements. Alterations produced by EDTA were more pronounced than those occurred with ascorbic acid and thiamin. Copper, zinc and iron levels in all tissues were drastically depleted by EDTA. The present results suggested that thiamin had the best efficacy as a metal chelating agent.

show abstract

The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood

Cited by 223 publications

References 55 publications

Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Management of Lead Encephalopathy with DMSA After Exposure to Lead-Contaminated Moonshine

Physiological studies of some chelating agents in accumulation of some heavy metals in Tilapa florida

Contact Info

Product

Resources

About