The use of chromophore gel-assisted blue light phototherapy (Lumiheal) for the treatment of surgical site infections in breast surgery

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

“…The lack of significant statistical differences between groups in the clinical secondary outcomes (Pruritus Severity Scale; Pain Severity Score; Aural temperature) helps demonstrate that LIG can have at least an equivalent clinical effect to the standard of care chosen. These results are very encouraging and well in line with the previous results reported with FB systems in humans suffering from diseases of QW group receiving LIG once weekly, BW group receiving LIG twice weekly, C group receiving standard of care twice daily, sd standard deviation, T 0 first evaluation time, T 5 sixth (last) evaluation time the skin, capable of accelerating healing, with reduced pain, and minimizing the clinical signs of bacterial colonization [22,29,32,[46][47][48][49][50]. Poly-microbial colonization often occurs in otitis externa and the continuum between mild-moderate colonization and the beginning of infection are blurred [51][52][53].…”

“…In this context, photobiomodulation (PBM) is widely known for its therapeutic benefits in the protection and regeneration of tissues [18][19][20][21][22][23]. Studies have demonstrated that PBM can reduce pain and inflammation [23][24][25], improve cancer management [26], and stimulate healing and tissue repair [20][21][22][27][28][29][30][31]. PBM is defined by the use of visible light to stimulate biological functions in a non-thermal and non-cytotoxic manner.…”

“…Fluorescence biomodulation (FB), a form of PBM that uniquely employs fluorescence light energy (FLE), has been demonstrated to advance healing of both acute and chronic wounds [22,[29][30][31]33]. A study has demonstrated that acute incisional wounds have reduced inflammation, as well as more physiologic re-epithelization and collagen remodelling, resulting in better quality and less visible scars [21].…”

Fluorescent light energy combined with systemic isotretinoin: A 52‐week follow‐up evaluating efficacy and safety in treatment of moderate‐severe acne

“…17,50 FLE has reported efficacy on a number of (inflammatory) skin conditions, including rosacea, 51,52 lentigines, 53,54 acneiform eruption, 55 acne conglobate, and hidradenitis suppurativa 56 as well as skin rejuvenation 57 and healing of acute and chronic wounds. 19,[58][59][60][61] In vitro findings have reported that FLE lowers production of essential pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in cultures of human epidermal keratinocytes and human dermal fibroblasts. [17][18][19] Finally, ongoing mechanistic studies suggest that FLE directly modify mitochondrial morphology and function.…”

“…This spectrum is facilitated by Stoke's shift phenomenon, describing fluorescence as chromophores absorbing photons from (blue) light and emitting them in a lower energy state of longer wavelengths, which compared with blue light penetrate and stimulate cells and structures in the deeper layers of the skin 17,50 . FLE has reported efficacy on a number of (inflammatory) skin conditions, including rosacea, 51,52 lentigines, 53,54 acneiform eruption, 55 acne conglobate, and hidradenitis suppurativa 56 as well as skin rejuvenation 57 and healing of acute and chronic wounds 19,58‐61 . In vitro findings have reported that FLE lowers production of essential pro‐inflammatory cytokines such as interleukin 6 (IL‐6) and tumor necrosis factor α (TNF‐α) in cultures of human epidermal keratinocytes and human dermal fibroblasts 17‐19 .…”