The use of citrus flavonoids in respiratory infections

Biskind, Morton S.; Martin, William Coda

doi:10.1007/bf02886384

Cited by 9 publications

(5 citation statements)

References 1 publication

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“…Indeed, Bauer et a1 (1981) established that a highly active synthetic antiviral flavonoid, 4,6-dichloroflavan (closely related to catechin), inhibits rhinovirus RNA synthesis without affecting virus adsorption and penetration into cells. Also, Limited studies suggest that some naturally occurring flavonoids can affect the outcome of virus infections in animals [Veckenstedt et al, 19781 and the controversy regarding the effect of flavonoids on the common cold [Biskind et al, 1954;Tebrock et al, 1956;Baird et al, 19791 may not be entirely settled yet. Since the average daily Western diet contains approximately 1 gm of mixed flavonoids [Kuhnau, 19761, it is possible that pharmacologically significant concentrations could be reached in tissues and influence the outcome of viral infections.…”

Section: Discussionmentioning

confidence: 99%

Antiviral effect of flavonoids on human viruses

Kaul¹,

Middleton²,

Ogra³

1985

Journal of Medical Virology

522

324

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The effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV-1), polio-virus type 1, parainfluenza virus type 3 (Pf-3), and respiratory syncytial virus (RSV) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction. Quercetin caused a concentration-dependent reduction in the infectivity of each virus. In addition, it reduced intracellular replication of each virus when monolayers were infected and subsequently cultured in medium containing quercetin. Preincubation of tissue culture cell monolayers with quercetin did not affect the ability of the viruses to infect or replicate in the tissue culture monolayers. Hesperetin had no effect on infectivity but it reduced intracellular replication of each of the viruses. Catechin inhibited the infectivity but not the replication of RSV and HSV-1 and had negligible effects on the other viruses. Naringin had no effect on either the infectivity or the replication of any of the viruses studied. Thus, naturally occurring flavonoids possess a variable spectrum of antiviral activity against certain RNA (RSV, Pf-3, polio) and DNA (HSV-1) viruses acting to inhibit infectivity and/or replication.

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Section: Discussionmentioning

confidence: 99%

Antiviral effect of flavonoids on human viruses

Kaul¹,

Middleton²,

Ogra³

1985

Journal of Medical Virology

522

324

View full text Add to dashboard Cite

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“…Co-administration of quercetin (12.5 mg/kg/week) and vitamin C and B 3 in a murine model of exercise-induced susceptibility to influenza H1N1 prolonged time-to-death (median time to death: placebo 9.0 ± 0.33 vs. quercetin 16.5 ± 1.2) and improved survival (mortality: placebo 74% vs. quercetin 52%) when compared to mice receiving only vitamins B3 and C (64). An older, small clinical trial identified the combination of flavonoids and ascorbic acid (1:1 ratio) as beneficial for respiratory infection (200 mg TID) (65).…”

Section: Beneficial Effects Of Vitamin C and Quercetin In Viral Infecmentioning

confidence: 99%

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

et al. 2020

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Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.

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“…147 Co-administration of Que (12.5 mg/kg/week) and vitamin C and B3 in a murine model of exercise-induced susceptibility to influenza H1N1 prolonged time-to-death (median time to death: placebo 9.0 ± 0.33 vs Que 16.5 ± 1.2) and improved survival (mortality: placebo 74% vs Que 52%) when compared with mice receiving only vitamins B3 and C. 102 An older, small clinical trial identified the combination of flavonoids and ascorbic acid (1:1 ratio) as beneficial for respiratory infection (200 mg thrice a day). 148 There is evidence that vitamin C and Que co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle Que, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic.…”

Section: Que and Vitamin Cmentioning

confidence: 99%

Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations

Agrawal¹,

Agrawal²,

Blunden

2020

Natural Product Communications

103

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Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry and replication cycle such as PLpro, 3CLpro, and NTPase/helicase. Due to its pleiotropic activities and lack of systemic toxicity, quercetin and its derivatives may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. There is evidence that quercetin in combination with, for example, vitamins C and D, may exert a synergistic antiviral action that may provide either an alternative or additional therapeutic/preventive option due to overlapping antiviral and immunomodulatory properties. This review summarizes the antiviral significance of quercetin and proposes a possible strategy for the effective utilization of natural polyphenols in our daily diet for the prevention of viral infection.

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The use of citrus flavonoids in respiratory infections

Cited by 9 publications

References 1 publication

Antiviral effect of flavonoids on human viruses

Antiviral effect of flavonoids on human viruses

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations

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