The use of cyanoacrylate tissue adhesive in high-risk intestinal anastomoses

Abstract

The success of every intestinal surgical procedure primarily depends on correct technical execution of the intestinal sutures. Despite the continuing improvements in intestinal synthesis techniques and the introduction of mechanical staplers, the risk of anastomotic dehiscence remains a major concern. For high-risk anastomoses, defined as those performed under critical conditions, n-butyl-2-cyanoacrylate tissue adhesive allows for quick sealing of the two stumps and supports the physiological wound-healing process. Furthermore, no experimental or clinical studies have shown that this glue has any carcinogenic or mutagenic properties. Thus, we believe that n-butyl-2-cyanoacrylate will be extremely useful for intestinal anastomoses with a high risk of dehiscence.

Estudo morfológico das entero-anastomoses com suturas em pontos separados complementados com adesivo sintético ou biológico em coelho

“…Em relação à concentração de granulomas, também não se observou diferença entre os grupos. Outros pesquisadores 32 também estudaram a aplicação dos adesivos sintético e biológico nas anastomoses intestinais e constataram formação de granuloma tipo corpo estranho 33 . O estudo comparativo entre a cola sintética e biológica demonstrou que tanto uma como a outra pode ser utilizada na síntese cirúrgica como suplemento e reforço de sutura.…”

Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?

“…Because histopathologic studies of cyanoacrylate-applied tissues revealed severe tissue reaction and inflammation, long-chain derivatives such as butyl cyanoacrylate and octyl cyanoacrylate were developed. These latter moieties lacked histotoxicity and were found to be safe for in vivo applications [12,15,[20][21][22]. In our study, histotoxicity was not evaluated; but it is known from the previous studies that mild to moderate tissue reaction with mononuclear cell migration and giant cell formation that was similar to those observed by the use of polyglactin 910 sutures might have been present [14,19].…”

Hernioplastia inguinal con malla sin tensión: Experiencia con adhesivo N-butil-cianoacrilato

“…El N-butil-cianocrilato o N-butil-2-cianocrilato, siendo también de cadena larga, ha demostrado particularmente poseer una respuesta inflamatoria mínima, conservando sus propiedades adhesivas 5,10,15 por lo que, de acuerdo a estudios, impresiona que se ha ido aumentando su utilización principalmente a nivel europeo, por ejemplo en cirugía abdominal, en anastomosis intestinales de alto riesgo 16 , o nefroptosis 17 , con comunicación de buenos resultados.…”