The use of DPPD (N,N1-diphenyl-p-phenylediamine) as an anti-inflammatory agent

Levy, Louis; Kerley, T.L.

doi:10.1016/0024-3205(74)90408-1

Cited by 9 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Control mice received 0.5 ml tocopherol-stripped corn oil alone. The dose levels (mg/kg body weight) for ip injection of each antioxidant were: BHT and BHA, 62.5, 215, and 500 (Branen, 1975;Saheb and Witschi, Downloaded by [New York University] at 03:42 08 February 2015 1975); DPPD, 50, 200, and 400 (Levy and Kerley, 1974);/7-propyl gallate, 50, 100, and 200 and ethoxyquin, 100, 200, and 400 (Torrielli and Ugazio, 1975;Wattenberg, 1972); and vitamin E, 15, 45, and 150 (Kamimura, 1972).…”

Section: Methodsmentioning

confidence: 99%

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

Omaye

Reddy

Cross

1977

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Toxic doses of butylated hydroxytoluene (BHT), a phenolic antioxidant commonly used as a food additive, are known to produce lung damage. In this study, 3 days after a single ip injection of 62.5, 215, or 500 mg/kg BHT in mice there was a dose-dependent increase in lung weight. This concentration dependence with injected BHT was accompanied by increases in lung DNA and nonprotein sulfhydryl levels and in whole lung tissue enzyme activities of glutathione (GSH) peroxidase, GSH reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase. The increased enzyme activities are considered to correspond to inflammatory and proliferative pulmonary changes resulting from acute lung cell injury and necrosis, which have been described previously, and cannot be construed as evidence for a primary oxidant-induced pulmonary lesion. The mechanism of BHT-induced lung changes may not be related to the antioxidant property of BHT, since vitamin E, n-propyl gallate, ethoxyquin, N,N'-p-phenylenediamine, and the structurally similar compound, butylated hydroxyanisole did not appear to produce the gross anatomical or biochemical lung changes observed with BHT.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

Omaye

Reddy

Cross

1977

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Despite good inhibition of arachidonate cyclo-oxygenase in vitro [12][13][14][15] and some moderate antiinflammatory effects in animal models [16][17][18][19][20][21][22][23], none of these antioxidants has produced potent anti-inflammatory activity by the oral route. Several years ago we began structural modification of H-transfer chain-breaking antioxidants such as BHT, BHA, and ethoxyquin.…”

Section: Figurementioning

confidence: 99%

2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties

Moore¹,

Swingle²

1982

Agents and Actions

View full text Add to dashboard Cite

R-830, a di-tert-butylphenol, has been shown to be anti-inflammatory in a number of animal models. These include conventional systems such as carrageenan-induced edema and adjuvant arthritis of the rat and ultraviolet-induced erythema in the guinea pig in which the acidic nonsteroidal anti-inflammatory drugs (e.g., indomethacin) are effective. The anti-inflammatory activity of R-830 has also been demonstrated in other models (e.g., graft vs. host reaction and reversed passive cutaneous Arthus reaction in the rat, contact sensitivity in the mouse) in which the acidic nonsteroidal drugs are not effective. In vitro, R-830 inhibits guinea pig lung lipoxygenase and bovine seminal vesicle cyclo-oxygenase. The antioxidant properties of R-830 were demonstrated in two in vitro systems. We speculate that the antioxidant activity of this molecule might be related to its unusual profile of pharmacological activity.

show abstract

Bedeutung und Wirkungsweise von Antioxidanzien

Bors¹

1987

Reaktive Sauerstoffspezies in Der Medizin

View full text Add to dashboard Cite

The use of DPPD (N,N1-diphenyl-p-phenylediamine) as an anti-inflammatory agent

Cited by 9 publications

References 6 publications

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties

Bedeutung und Wirkungsweise von Antioxidanzien

Contact Info

Product

Resources

About