The use of fenbendazole in the treatment of commercial turkeys infected with<i>Ascaridia dissimilis</i>

Yazwinsri, T. A.; Rosenstein, M.; Schwartz, Roger D.; Wilson, K. I.; Johnson, Z. B.

doi:10.1080/03079459308418909

Cited by 27 publications

(14 citation statements)

References 4 publications

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“…; Yazwinski et al. , ). Lawrence () showed that a single treatment with fenbendazole eliminated all nematode parasites in 221 of 230 birds from 38 species of six orders.…”

Section: Methodsmentioning

confidence: 98%

“…In order to minimize the time spent at the nest and thus the invasiveness of the study, we did not attempt to quantify the reduction in parasite levels in relation to the treatment. Yet, several studies have shown that fenbendazole is effective against various intestinal parasites in birds, for example nematodes, lungworms, and cestodes (Norton et al 1991;Yazwinski et al 1992Yazwinski et al , 1993. Lawrence (1983) showed that a single treatment with fenbendazole eliminated all nematode parasites in 221 of 230 birds from 38 species of six orders.…”

Section: Methodsmentioning

confidence: 99%

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Antiparasite treatments reduce humoral immunity and impact oxidative status in raptor nestlings

Hanssen

Bustnes

Schnug

et al. 2013

Ecology and Evolution

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Parasites are natural stressors that may have multiple negative effects on their host as they usurp energy and nutrients and may lead to costly immune responses that may cause oxidative stress. At early stages, animals may be more sensitive to infectious organisms because of their rapid growth and partly immature immune system. The objective of this study was to explore effects of parasites by treating chicks of two raptor species (northern goshawk Accipiter gentilis and white-tailed sea eagle Haliaeetus albicilla) against both endoparasites (internal parasites) and ectoparasites (external parasites). Nests were either treated against ectoparasites by spraying with pyrethrin or left unsprayed as control nests. Within each nest, chicks were randomly orally treated with either an antihelminthic medication (fenbendazole) or sterile water as control treatment. We investigated treatment effects on plasma (1) total antioxidant capacity TAC (an index of nonenzymatic circulating antioxidant defenses), (2) total oxidant status TOS (a measure of plasmatic oxidants), and (3) immunoglobulin levels (a measure of humoral immune function). Treatment against ectoparasites led to a reduction in circulating immunoglobulin plasma levels in male chicks. TOS was higher when not receiving any parasite reduction treatment and when receiving both endo- and ectoparasitic reduction treatment compared with receiving only one treatment. TAC was higher in all treatment groups, when compared to controls. Despite the relatively low sample size, this experimental study suggests complex but similar relationships between treatment groups and oxidative status and immunoglobulin levels in two raptor species.

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“…; Yazwinski et al. , ). Lawrence () showed that a single treatment with fenbendazole eliminated all nematode parasites in 221 of 230 birds from 38 species of six orders.…”

Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Antiparasite treatments reduce humoral immunity and impact oxidative status in raptor nestlings

Hanssen

Bustnes

Schnug

et al. 2013

Ecology and Evolution

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“…The drug is effective against various intestinal parasites in birds e.g. nematodes, lungworms and cestodes (Norton et al 1991, Yazwinski et al 1992, Yazwinski et al 1993), and may also be effective against acanthocephala as another benzimidazole (albendazole) has been reported to cure acanthocephala infections in monkeys (Weber and Junge 2000). Additionally, no negative side effects of fenbendazole have been shown in domestic ducks (Short et al 1988, Pedersoli et al 1989).…”

Section: Methodsmentioning

confidence: 99%

Costs of parasites in common eiders: effects of antiparasite treatment

Hanssen¹,

Folstad²,

Erikstad³

et al. 2003

Oikos

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Parasites are exploiting their host for the resources required for the parasite's reproduction and survival. The effects of antiparasitic treatment during incubation on body mass and return rate in female common eiders Somateria mollissima were examined in a two year study (1998 and 1999). There was no effect of treatment on nest success, but unsuccessful females had lower body mass. Treatment had no effect on incubation time, mass‐loss during incubation or return rate among successful birds. However, treatment lead to higher return rate among unsuccessful birds (treated=69%, n=13; controls=18%, n=11). This pattern remained significant also after including the birds that returned two years after the experiment. We suggest that the unsuccessful females are of lower quality and had higher costs from parasite infections than birds which completed incubation, and that the higher return rate for treated unsuccessful females may mean that costs of parasites are substantial, and that the potential fitness gain from investment in parasite defense and avoidance is large.

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“…However, another study indicated that ALB can be effective in protection of turkeys against Heterakis gallinarum or flagellated form of Histomonas (Hegngi et al , ). Clinical effectiveness in the treatment of turkeys infected by Ascaridia dissimilis is described for homologous drug fenbendazole (Yazwinski et al , ). Unfortunately, both ALB studies were performed without any knowledge of the pharmacokinetics of ALB and its active metabolite SOX.…”

Section: Introductionmentioning

confidence: 99%

Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys

Grabowski

Jaroszewski

Swierczewska

et al. 2011

Biomed. Chromatogr.

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Methods for determination of albendazole (ALB), albendazole sulfoxide (SOX) and albendazole sulfone (SON) in turkey blood plasma, using high-performance liquid chromatography (HPLC) with fluorescence detection, were developed. Moreover, comparison of HPLC columns with ultra-performance liquid chromatography (UPLC) columns was performed. Albendazol was administered orally in 5-week-old birds (n = 18) at a dose of 25 mg/kg b.w. Accuracy and precision of the developed method were satisfactory and stability studies showed acceptable variation (below 15%) in ALB, SOX and SON concentrations when the samples were stored at -75°C for 15 days. UPLC(®) columns gave higher peaks from typical HPLC columns retaining high quality of analysis. Pharmacokinetic analysis indicated quick elimination of ALB from turkey blood plasma. The mean residence time of SON was at least two times longer than that of SOX and four times longer than that of ALB. The elimination half-lives for ALB, SOX and SON were 0.7 ± 0.27, 5.37 ± 6.03, 9.17 ± 5.12 h, respectively. The obtained results indicate that the described method allows for precise determination of albendazole and its metabolites in turkey plasma. Moreover, using UPLC columns in HPLC apparatus results in higher sensitivity as compared with the classical HPLC columns.

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The use of fenbendazole in the treatment of commercial turkeys infected withAscaridia dissimilis

Cited by 27 publications

References 4 publications

Antiparasite treatments reduce humoral immunity and impact oxidative status in raptor nestlings

Antiparasite treatments reduce humoral immunity and impact oxidative status in raptor nestlings

Costs of parasites in common eiders: effects of antiparasite treatment

Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys

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