The use of fine-needle aspiration biopsy in detection of acute rejection in children after liver transplantation

Their, Maria; Lautenschlager, Irmeli; Willebrand, E von; Höckerstedt, K; Holmberg, Christer; Jalanko, Hannu

doi:10.1111/j.1432-2277.2002.tb00159.x

Cited by 6 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…performed 824 fine‐needle aspiration biopsies after 63 pediatric liver transplantations. Rejection episodes were detected in 62% of the patients and often diagnosed before clinical signs were present . Following liver transplantation for biliary atresia, the incidence of chronic rejection or fibrosis was reported to be 73% in transplant recipients, 10 yr after transplantation .…”

Section: Discussionmentioning

confidence: 99%

“…However, because children lacking clinical and laboratory signs of rejection do not routinely undergo liver biopsies in most pediatric transplant centers, few data are available in the pediatric setting. Still, several reports show that protocol biopsies in pediatric liver transplant patients presenting with normal liver function tests revealed unexpected fibrosis, acute or chronic rejection, or signs of hepatitis and that increasing their immunosuppressive medications presumably reduced tissue damage . Moreover, the role of scheduled liver biopsies becomes more important when the goal is to minimize or wean off the immunosuppressive medications .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Liver allograft pathology in healthy pediatric liver transplant recipients

Briem-Richter

Ganschow

Sornsakrin

et al. 2013

Pediatric Transplantation

View full text Add to dashboard Cite

Liver transplantation offers excellent results for children with end-stage liver disease, and efforts should be directed toward maintaining long-term graft health. We evaluate graft pathology in healthy pediatric transplant recipients with low-maintenance immunosuppressive medications to assess whether protocol biopsies are helpful for adapting immunosuppression and protecting long-term graft function. Liver biopsies were performed on 60 healthy pediatric liver transplant recipients, and histological findings were correlated with laboratory, serological, and radiological results. Fourteen patients (23%) were diagnosed with acute or early chronic rejection, and immunosuppressive medications were increased in these children. Liver function tests did not correlate with histological findings. The incidence of fibrosis was 36% in transplant recipients five or more years after liver transplantation. We observed an unexpectedly high prevalence of rejection and fibrosis in children with no laboratory abnormalities, which led to changes in their immunosuppressive medications. Scheduled biopsies appear to be useful in pediatric transplant recipients with low immunosuppressive medications for early detection of morphological changes in liver transplants. Further studies are needed to evaluate whether adaption of immunosuppression helps to reduce tissue damage and the incidence of allograft dysfunction in the long term.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Liver allograft pathology in healthy pediatric liver transplant recipients

Briem-Richter

Ganschow

Sornsakrin

et al. 2013

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…As bilirubin as a disease severity marker is not relevant in OCT-deficiency and hyperoxaluria, patients with these diagnoses were excluded from these analyses. The diagnosis of acute rejection following LTx was mainly based on fine-needle aspiration biopsy (19), taken routinely twice a week before discharge from the hospital, or with acute rejection suspected clinically. Acute rejections were treated with 3-10 mg/kg methylprednisolone for 3-5 days.…”

Section: Methodsmentioning

confidence: 99%

Visuospatial impairment in children and adolescents after liver transplantation

Haavisto

Korkman

Törmänen

et al. 2010

Pediatric Transplantation

Self Cite

View full text Add to dashboard Cite

A minority of children with liver transplants exhibit significant delay in global intelligence; others have specific learning disabilities. More specific data on neurocognitive strengths and weaknesses are lacking. Eighteen children aged 7-16 yr, who had undergone LTx in Finland participated in the study. They were assessed on an average 7.6 (s.d. 4.5, range 1.0-15.0) years post-operatively at a mean age of 11.8 (s.d. 3.1, range 7.2-16.1). A standardized test of intelligence (WISC-III), a neuropsychological test battery (NEPSY-II), and a parental questionnaire on the child's development (FTF) were administered. The neuropsychological test profile of the LTx group was compared with that of a matched control group of healthy children. The LTx children achieved on an average normal FSIQ 94.0 and VIQ 99.6. Their Performance Intelligence Quotient (PIQ 88.9, p=0.043) was, however, significantly lower than the population mean. On neuropsychological assessment, the LTx children scored generally lower than the control group (p=0.004), a difference significant in sub-tests assessing visuospatial and visuoconstructive functions and social perception. No differences emerged in sub-tests of attention and executive functions, memory and learning, or language functions. LTx children are at increased risk for impairment in the visuospatial domain.

show abstract

Liver and spleen

Boer¹

2012

Orell and Sterrett's Fine Needle Aspiration Cytology

View full text Add to dashboard Cite

The use of fine-needle aspiration biopsy in detection of acute rejection in children after liver transplantation

Cited by 6 publications

References 18 publications

Liver allograft pathology in healthy pediatric liver transplant recipients

Liver allograft pathology in healthy pediatric liver transplant recipients

Visuospatial impairment in children and adolescents after liver transplantation

Liver and spleen

Contact Info

Product

Resources

About