The use of gamma-glutamyl transpeptidase in differentiating liver from bone isoenzymes of alkaline phosphatase

Kampa, Ingo S.; Jarzabek, Jean I.; Clain, Jean

doi:10.1016/s0009-9120(76)80066-5

Cited by 7 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is true that patients receiving some drugs, particularly antiepileptic drugs such as barbituates and phenytoin, have significantly increased -y-GTP activity (26,27). However, the enzyme is increased in almost every form of hepatobiliary disease (36,(38)(39)(40)(41) and because the test is among the most sensitive, it will be elevated in subtle forms of liver injury such as resolution of asymptomatic viral hepatitis (42). y-GTP is also elevated in diabetes or other pancreatic diseases (31,43), in kidney diseases (44) and, for reasons that are unclear, with congestive heart failure (45), angina (46) myocardial infarction (47) and many other conditions (48), even though there may be no apparent effect of these diseases on the liver.…”

mentioning

confidence: 99%

Clinical evaluation of liver structure and function in humans exposed to halogenated hydrocarbons.

Guzelian¹

1985

Environ Health Perspect

View full text Add to dashboard Cite

An unresolved question is whether humans exposed to comparatively low doses of persistent environmental chemicals such as polyhalogenated biphenyls or organochlorine pesticides are at risk for injury to the liver. Cross-sectional epidemiologic studies suggest that these chemicals may produce statistically significant but clinically mild abnormalities in the commonly employed chemical tests of liver function. The few reports of human liver morphology reveal nonspecific changes reflecting effects of lipophilic chemicals. There is evidence that chemicals of this category in at least some doses cause induction of liver microsomal enzymes involved in biotransformation of foreign substances. This finding has been documented by measurements of the clearance of model drugs or the appearance in the urine of steroid metabolites or glucaric acid. Although a positive statistical correlation between the concentrations of these chemicals in serum and the serum gamma-glutamyltranspeptidase activity has been reported, the non-specificity of the latter enzyme precludes conclusion that this change is indicative of induction of liver microsomal enzymes. Although the effects of this type of environmental chemical are not indicative of progressive liver disease, only prospective clinical trials can resolve the issue of the risk for future development of liver malignancy.

show abstract