The use of germ-free and specific pathogen-free rats in short-term experiments for the assessment of potentially cariogenic organisms

Effect of Xylitol-Supplemented Diets on the Progression and Regression of Fissure Caries in the Albino Rat

“…The length of the experimental period for each treatment is shown in tables I-V. All diets used in these experiments were based on a modified Ste phan 580 diet [Blackmore and Green, 1970]. The carbohydrate fraction (65.5%) consisted of either sucrose, maize starch or a maize starch/xylitol mixture.…”

Reversal of Fissure Caries in the Albino Rat by Stimulating Salivary Flow with Pilocarpine (Short Communication)

“…All animals were first fed for 6 days on a modified Stephan 580 diet [Blackmore and Green, 1970] from each block was sacrificed to establish a baseline caries measurement and the remaining animals fed a similar diet for a further 15 days in which the sucrose had been replaced by 65.5% uncooked maize starch and to which had been added pilocarpine hydrochlo ride (Sigma, Dorset, UK), as shown in tables 1 and 2.…”

Reversal of Fissure Caries in the Albino Rat by Sweetening Agents

“…To this end 16 litters of weanling rats (21-23 days old) from our Liverpool colony with their normal background cariogenic flora were all first fed a modified Stephan 580 diet [Blackmore and Green, 1970] containing 65.5% sucrose for 5 days, followed by a diet containing 65.5% of fine ly powdered raw maize starch, or one in which part of the starch had been replaced by either sucrose, xylitol, equal parts of mannitol and sorbitol, or Talin as shown in table I. All the diets were ground so as to pass a 200 mesh sieve.…”