The use of GnRH analogs in preserving ovarian function during chemotherapy

Abstract

Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When it comes to preserving fertility, it is crucial to consider all available options in this topic due to its very sensitive nature, thereby we have found that while a lot of trials favor the use of gonadotropin-releasing hormone agonists, the lack of proper follow-up and long-term trials renders its use highly debatable, and since the longest follow-up trial showed non-significant results, it also opens the floor for debate on whether this short-term benefit is worth adding another drug to the regimen or not. Short conclusion As described in this review, while the use of gonadotropin-releasing hormone agonists is beneficial in a lot of studies, the lack of long-term reports still makes its use debatable, thereby more trials should be done.

Classical music restored fertility status in rat model of premature ovarian failure

“…Different clinical symptoms such as amenorrhea, hypoestrogenism (estrogen reduction), and hyper-gonadotropism (increased levels of gonadotropins) can be manifested in POF women [6]. Until now, various pre-clinical strategies have been developed for the treatments of POF including hormone replacement therapy (HRT), gonadotropinreleasing hormone (GnRH) application, and modalities that are associated with the application of whole-cell, or cell-based products [7][8][9][10][11][12][13][14].…”