The Use of Green Spectroscopy for Analysis of Quetiapine

Abstract

Three green (eco-friendly), inexpensive and simple spectrophotometric methods for quetiapine fumarate (QTF) analysis have been developed and validated. Method I is based on the measurement of the oxidation product of QTF at 610 nm after the reaction with potassium permanganate. Potassium permanganate was used as oxidant. Method II depends on oxidation of the cited drug with ceric ammonium sulfate where the decrease in absorption intensity at 315 nm was measured quantitively. Method III involves complexation of the studied analyte with 2´,7´-bis (acetoxymercury) fluorescein leading to a quantitative decrease in the absorption intensity of the complexing reagent at 502 nm. Different reaction conditions affecting intensity of measurement were carefully studied, optimized and validated. In all proposed methods, no need for extraction procedures and there were linear relationships between the absorbance readings and concentrations of QTF in the range of 5-35, 1-6 and 30-100 μg/mL with LOD values 1.11, 0.12 and 2.68 μg/mL for methods I, II and III respectively. The suggested methods were successfully applied to QTF analysis in pure form and in drug tablets.