The Use of Human Acellular Dermal Matrix for Chest Wall Reconstruction

Ge, Phillip S.; Imai, Taryne A.; Aboulian, Armen; Natta, Timothy L. Van

doi:10.1016/j.athoracsur.2010.07.080

Cited by 28 publications

(19 citation statements)

References 24 publications

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“…[23567] Ideally, the adopted material should have high tensile strength, elasticity, longevity, ease of use, high biocompatibility and low affinity to bacterial adhesion. A good secondary incorporation into adjacent tissue could limit calcification and fibrosis, thus reducing adhesion formation between chest wall and lung and possibly facilitating redo-procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, routine clinical implementation is not yet foreseeable. [7] Procedures with muscle transfer techniques ( Musculus latissimus dorsi , Musculus rectus abdominis ) lead to overall good clinical results due to reliance on autologous materials, but tend to significantly lengthen overall operating time and often require implementation of microvascular techniques. [17] Even though biological materials may prove a viable alternative, at present no real long-term data is available.…”

Section: Discussionmentioning

confidence: 99%

“…[8] Bioartifical materials may overcome most of the aforementioned shortcomings, but are still to be considered as largely experimental at this stage. [7]…”

mentioning

confidence: 99%

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Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

Zardo

Zhang

Freermann³

et al. 2014

Ann Thorac Med

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PURPOSE:Novel composite meshes routinely used in laparoscopic hernia repair reportedly lead to fewer and less dense visceral adhesions and may provide a viable alternative in thoracic surgery as well.METHODS:A total of 15 adult domestic pigs underwent full thickness chest wall resection and reconstruction with Parietene (polypropylene composite; PTE, n = 5), Parietex (polyester composite; PTX, n = 5) or Bard (purely polypropylene, n = 5) mesh. After an observation period of 90 days all animals were sacrificed, intrathoracic adhesions classified via thoracoscopy (VATS), meshes explanted and peak peal strength required for lung/mesh separation recorded.RESULTS:Adhesions assessed through VATS-exploration were strongest in the PTX-Group while PTE and BM showed comparable results. Tensiometric analyses of peak peal strength confirmed lower values in BM than for PTE and PTX. Both composite materials showed good overall bioincorporation with post-surgical perigraft-fibrosis being strongest in BM.CONCLUSION:We consider composite grafts a suitable alternative for chest wall reconstruction. They are characterized by good overall biointegration and limited perigraft-fibrosis, thus potentially facilitating redo-procedures, even though a hydrophilic coating per se does not appear to prevent intrathoracic adhesion formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

Zardo

Zhang

Freermann³

et al. 2014

Ann Thorac Med

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“…It provides a natural template for cellular migration and repopulation that guides normal tissue regeneration. ADM, initially utilized in burn surgery, has then been widely applied in plastic surgery [4], abdominal hernia repair [5], reconstruction of chest wall [6], and oral mucosal repair [7]. Xenogenic acellular dermal matrix (xeno-ADM) is derived from mammalian skin.…”

Section: Introductionmentioning

confidence: 99%

Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects

Yang

et al. 2016

Eur Arch Otorhinolaryngol

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Acellular dermal matrix (ADM) can be used as a new membrane substitute for repairing mucosal defects. The objective of this study is to explore the effectiveness of xenogenic acellular dermal matrix (xeno-ADM) in hypopharynx reconstruction. A total of 40 patients were treated with this surgical method to reconstruct hypopharynx in our department between February 2011 and October 2012. Patients were diagnosed had hypopharyngeal cancer located at lateral and/or postpharyngeal wall. The mucosal defect size after hypopharyngeal resection was 3 × 4 cm-6 × 7 cm, and was repaired by xeno-ADM. Patients were followed up for 11-36 months. 4 patients got infected, and two developed into pharyngeal fistula. Patients regained eating function 2-5 weeks after surgery. No membrane was removed; no severe stenosis of hypopharynx was observed. All patients were successfully decannulated. The overall 3-year survival rate is 67.5 %; the 3-year disease-free rate is 47.5 %. Reconstruction of hypopharynx by xeno-ADM is proved to be a simple, safe and effective method with fewer complications.

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“…또한 조직재건 및 미용성형, 전층부 창상, 화상 등 피부치료제로써의 이용범위도 확대되고 있다 [9][10][11]. 그러나 사체기증의 어려움 및 합성고분자 치료제에 비교해 동일면적 대비 고가의 가격으로 인해 선택의 폭이 좁 은 실정이다 [12]. 본 연구에서는 기존 치료제의 기능적 단점을 보완하고 치 료능을 극대화하기 위해 1형 콜라겐을 이용해 분쇄 무세포진 피와 피부세포를 혼합한 인공피부를 개발하고자 하였다.…”

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Application of a Composite Skin Equivalent using Collagen and Acellular Dermal Matrix as the Scaffold in a Mouse Model of Full-thickness Wound

이동혁¹,

윤진철²,

이정희³

et al. 2014

KSBB Journal

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The aim of this study was to develop a composite human skin equivalent for wound healing. Collagen type1 and acellular dermal matrix powder were utilized as the scaffold with dermal fibroblasts and keratinocytes for the development of a composite human skin equivalent. Fibroblast maintained the volume of composite skin equivalent and also induced keratinocytes to attach and proliferate on the surface of composite skin equivalent. The composite human skin equivalent had a structure and curvature similar to those of real skin. Balb-C nu/nu mice were used for the evaluation of full-thickness wound healing effect of the composite human skin equivalent. Graft of composite skin equivalent on full-thickness wound promoted re-epithelialization and granulation tissue formation at 9 days. Given the average wound-healing time (14 days), the wound in the developed composite skin equivalent healed quickly. The overall results indicated that this three-dimensional composite human skin equivalent can be used to effectively enhance wound healing.

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The Use of Human Acellular Dermal Matrix for Chest Wall Reconstruction

Cited by 28 publications

References 24 publications

Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects

Application of a Composite Skin Equivalent using Collagen and Acellular Dermal Matrix as the Scaffold in a Mouse Model of Full-thickness Wound

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