The use of indocyanine green and near-infrared fluorescence imaging to assist sentinel lymph node biopsy in cutaneous melanoma: A systematic review

Lafrenière, Ann‐Sophie; Shine, Julien J.; Nicholas, Colin; Temple‐Oberle, Claire

doi:10.1016/j.ejso.2020.10.027

Cited by 15 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent systematic review of 1,209 patients with cutaneous melanoma reported an SLN detection rate of 86%-100% when using NIR fluorescence with ICG, 86%-100% when using radiotracer, and 43%-73% when using blue dye [ 10 ]. Additionally, 2% of nodes were detected only by ICG and not by any other technique.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, 2% of nodes were detected only by ICG and not by any other technique. The rate of missed nodes with ICG was heterogenous, ranging from 0% to 13.7% [ 10 ]. All of the studies used ICG in addition to preoperative lymphoscintigraphy, as we did.…”

Section: Discussionmentioning

confidence: 99%

“…The use of NIR fluorescence with ICG still has its own shortcomings and challenges to overcome. There is significant heterogeneity among studies regarding ICG preparation and imaging protocol [ 10 ]. This introduces biases that may affect the results of individual studies.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Near-Infrared Fluorescence Imaging for Sentinel Lymph Node Identification in Melanoma Surgery

Ferri

Montorfano

Bordes

et al. 2021

Cureus

View full text Add to dashboard Cite

Although less common than other types of skin cancers, melanoma is accountable for the majority of skin cancer-related deaths. The standard management for patients with clinically negative nodes includes a sentinel lymph node (SLN) biopsy, which is commonly performed using a combination of radioactive tracer (Tc-99) and a blue dye (isosulfan or patent blue). There are numerous drawbacks associated with Tc-99 and blue dyes such as elevated costs, logistical challenges, and anaphylactic reactions among others. In recent years, near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has emerged as a safe, effective, less costly, and more convenient alternative for the identification of SLNs in melanoma. We discuss the case of a 51-year-old man with melanoma in his left upper back. Two SLNs in the left axilla were successfully identified using NIR fluorescence. NIR fluorescence with ICG for SLN identification has proven to increase the sensitivity and accuracy when used in combination with lymphoscintigraphy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Near-Infrared Fluorescence Imaging for Sentinel Lymph Node Identification in Melanoma Surgery

Ferri

Montorfano

Bordes

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…Near-infrared (NIR) FGS is being used clinically in some medical centers as it penetrates more deeply in tissues than fluorescence in the visible light range. Anti-carcinoma embryonic antigen (CEA) and cancer antigen (CA)19-9 antibodies, and bevacizumab, conjugated with NIR fluorophores, have been used preclinically and are beginning to be used clinically for gastrointestinal surgery [ 65 , 66 , 67 , 68 ]. In a few large medical centers, 5-aminolevulinic acid (5-ALA) is used for fluorescence-guided surgery of highly invasive glioblastoma multiforme (GBM).…”

Section: Oncolytic Gfp Reporter Virus For Fluorescence-guided Surgmentioning

confidence: 99%

Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment

Yano

Tazawa

Kishimoto

et al. 2021

IJMS

View full text Add to dashboard Cite

Oncolytic virotherapy is one of the most promising, emerging cancer therapeutics. We generated three types of telomerase-specific replication-competent oncolytic adenovirus: OBP-301; a green fluorescent protein (GFP)-expressing adenovirus, OBP-401; and Killer-Red-armed OBP-301. These oncolytic adenoviruses are driven by the human telomerase reverse transcriptase (hTERT) promoter; therefore, they conditionally replicate preferentially in cancer cells. Fluorescence imaging enables visualization of invasion and metastasis in vivo at the subcellular level; including molecular dynamics of cancer cells, resulting in greater precision therapy. In the present review, we focused on fluorescence imaging applications to develop precision targeting for oncolytic virotherapy. Cell-cycle imaging with the fluorescence ubiquitination cell cycle indicator (FUCCI) demonstrated that combination therapy of an oncolytic adenovirus and a cytotoxic agent could precisely target quiescent, chemoresistant cancer stem cells (CSCs) based on decoying the cancer cells to cycle to S-phase by viral treatment, thereby rendering them chemosensitive. Non-invasive fluorescence imaging demonstrated that complete tumor resection with a precise margin, preservation of function, and prevention of distant metastasis, was achieved with fluorescence-guided surgery (FGS) with a GFP-reporter adenovirus. A combination of fluorescence imaging and laser ablation using a KillerRed-protein reporter adenovirus resulted in effective photodynamic cancer therapy (PDT). Thus, imaging technology and the designer oncolytic adenoviruses may have clinical potential for precise cancer targeting by indicating the optimal time for administering therapeutic agents; accurate surgical guidance for complete resection of tumors; and precise targeted cancer-specific photosensitization.

show abstract

“…9 A recent systematic review has identified the potential usefulness of ICG as an adjunct to traditional sentinel node biopsy techniques. 10 Herein we demonstrate the use of ICG in the case of a man undergoing a SLNB of the head and neck area for a melanoma located at the angle of the mandible. In this individual, radiotracer failed to migrate.…”

Section: Introductionmentioning

confidence: 99%

Failure of Radiotracer Migration: Salvaging Sentinel Lymph Node Biopsy in Melanoma Care With Indocyanine Green

Nicholas

Webb

Temple‐Oberle

2021

Plastic Surgery Case Studies

View full text Add to dashboard Cite

Reducing false negative rates for sentinel lymph node biopsies (SLNB) in melanoma is important to accurately prognosticate and to guide treatment. Traditionally, SLNB has been performed with the adjunct of radiotracers and blue dye. Although sentinel node mapping is highly successful in axillary and inguinal node basins, identification of nodes in the head and neck is not as accurate with traditional methods. One reason for this may be failure of radiotracer migration. To augment standard technique using a radiocolloid, indocyanine green (ICG) combined with near infrared spectroscopy (NIRS), has shown promising results. We demonstrate a case of an individual undergoing SLNB in the head and neck region with failure of radiotracer migration. Identification of a sentinel node was accomplished with the use of ICG and NIRS. This technology offers an opportunity to salvage the SLNB when traditional methods fail.

show abstract

The use of indocyanine green and near-infrared fluorescence imaging to assist sentinel lymph node biopsy in cutaneous melanoma: A systematic review

Cited by 15 publications

References 31 publications

Near-Infrared Fluorescence Imaging for Sentinel Lymph Node Identification in Melanoma Surgery

Near-Infrared Fluorescence Imaging for Sentinel Lymph Node Identification in Melanoma Surgery

Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment

Failure of Radiotracer Migration: Salvaging Sentinel Lymph Node Biopsy in Melanoma Care With Indocyanine Green

Contact Info

Product

Resources

About