The use of lidocaine as an anti-inflammatory substance: A systematic review

Caracas, Hugo Cesar Pinto Marques; Maciel, José Vinicius Bolognesi; Martins, Patrícia; Souza, Margareth Maria Gomes de; Maia, Lucianne Cople

doi:10.1016/j.jdent.2008.10.005

Cited by 93 publications

(63 citation statements)

References 19 publications

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“…Lidocaine as a sodium channel blocker has analgesic, antihyperalgesic, and anti-inflammatory effects [5,6]. Perioperative IV lidocaine infusion improves postoperative outcomes such as pain score, postoperative analgesic consumption, anti-inflammatory response, bowel function, and hospital LOS, particularly after visceral surgery [1][2][3][4]7,8].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men

Kang

Kim

et al. 2012

Journal of Clinical Anesthesia

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Section: Introductionmentioning

confidence: 99%

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men

Kang

Kim

et al. 2012

Journal of Clinical Anesthesia

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“…Indeed, an intravenous lidocaine infusion has been used to control chronic pain owing to its local anesthetic and anti-inflammatory properties. 2,3 Future studies will evaluate the use of lidocaine for nerve block infusion and will assess its systemic analgesic effects. …”

Section: To the Editormentioning

confidence: 99%

Lidocaine infusion for continuous interscalene nerve block: Is there evidence for local and systemic benefits?

Tsui

2014

Can J Anesth/J Can Anesth

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To the Editor,We read with interest the case report by BurckettSt.Laurent et al. 1 describing ultrasound-guided superior trunk block as an alternative approach to interscalene block with the potential to reduce inadvertent phrenic nerve blockade. We applaud their excellent work and herein describe an approach we have used to minimize adverse respiratory effects following interscalene block.A 54-yr-old male (body mass index 52.2) was scheduled for a left shoulder hemiarthroplasty. He had a history of well-controlled asthma on salbutamol and also suffered obstructive sleep apnea, which was managed at night with continuous positive airway pressure. He was taking Oxycocet every six hours along with diclofenac to manage chronic arthritic back and knee pain. The patient consented to undergo the interscalene block after being apprised of the block's susceptibility to phrenic nerve blockade consequent with its analgesic benefits.A left interscalene MultiSet 211156-40E catheter-overneedle assembly (Pajunk GmbH; Geisingen, Germany) was inserted using the conventional technique with an out-ofplane approach between the C5 and C6 roots. Nevertheless, the catheter was not injected until five minutes before induction of general anesthesia, at which time 5 mL of local anesthetic (0.5% ropivacaine:0.125% bupivacaine 1:1) were administered. The intraoperative period was uneventful, and the patient was comfortable in the postanesthesia care unit with a good sensory block of the C5-8 regions. To provide the volume necessary for adequate blockade, an infusion of 0.4% lidocaine at 3 mLÁhr -1 was initiated with pre-planned hourly 3-mL bolus doses throughout the time the catheter remained in place. We reasoned that, in the event of respiratory compromise, the lidocaine infusion could be stopped with a relatively quick offset compared with other local anesthetics.Postoperatively, the patient was comfortable with a visual analogue scale pain score\3. No symptoms or signs of respiratory compromise or local anesthetic toxicity were observed. The only other pain control used was his usual home analgesics. We discontinued the infusion on postoperative day two. Interestingly, the patient started experiencing more back and knee pain less than two hours after discontinuing the infusion.Several interesting aspects emerged from this case. Firstly, injecting local anesthetic through the interscalene catheter just prior to induction may avoid subjective effects from phrenic nerve blockade. Secondly, if respiratory compromise should occur, the use of lidocaine may avoid a prolonged course. Thirdly, we did not need to increase the local anesthetic infusion, suggesting no clinically significant catheter migration for at least 48 hours. Lastly, the lidocaine infusion appeared to have relieved the patient's chronic arthritic pain. Indeed, an intravenous lidocaine infusion has been used to control chronic pain owing to its local anesthetic and anti-inflammatory properties. 2,3 Future studies will evaluate the use of lidocaine for nerve block infusion and...

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“…The anti-inflammatory properties of local anesthetics (LAs) are widely documented and suggested to be more potent than conventional NSAIDs or steroidal agents [11]. The LAs are also documented to devoid of potential side-effects, which generally found in traditional anti-inflammatory agents because of their effect on immune cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

李武¹,

Lu²,

Wang³

et al. 2019

Pharmacology

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The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E₂, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation.

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The use of lidocaine as an anti-inflammatory substance: A systematic review

Cited by 93 publications

References 19 publications

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men

Intraoperative intravenous lidocaine reduces hospital length of stay following open gastrectomy for stomach cancer in men

Lidocaine infusion for continuous interscalene nerve block: Is there evidence for local and systemic benefits?

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

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