Using a shake-table, the effects of several stone pebble layer parameters (the layer thickness, the fraction of pebbles, the pebble compaction, the pebble moisture, the vertical contact stress below the foundation, and the effect of repeated excitations) on layer aseismic efficiency were investigated. For each considered parameter, a model of a rigid building on an aseismic layer was exposed to four different accelerograms, with three levels of peak ground acceleration (PGA), while all other layer parameters were kept constant. For each test, the characteristic displacements and accelerations were measured. Based on the test results, the main conclusions regarding the effect of the considered parameters on the effectiveness of the adopted aseismic layer are given.