The use of mannitol in neurosurgery and neuro-ophthalmology

Turliuc, Mihaela Dana; Cucu, Andrei; Costăchescu, B.; TUDOR, ROXANA M.; Papacocea, Toma; Bogdănici, Camelia Margareta; Cărăuleanu, Alexandru; Floria, Mariana; Costea, Claudia Florida

doi:10.35812/cellulosechemtechnol.2019.53.61

Cited by 5 publications

(3 citation statements)

References 77 publications

(116 reference statements)

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“…Mannitol has diuretic properties and is sometimes used as a natural sweetener. It may have possible applications in the management of certain medical conditions, such as glaucoma and cerebral edema [101].…”

Section: Tremella Mesenterica (T Mesenterica)mentioning

confidence: 99%

Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications

Hassan,

Shahzadi,

Ransom

et al. 2023

IJMS

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Mushrooms are new potential sources of valuable medicines, long neglected because of difficulties experienced in their cultivation. There is a large variety of medicinal mushrooms which possess significant therapeutic properties and are used as medications for various diseases because they contain several novel highly bioactive components. Medicinal mushrooms can be identified based on their morphology, size, mass, and the color of the stalk, cap and spore, and attachment to the stalk. Medicinal mushrooms possess a variety of important biological activities and are used as antioxidants, hepatoprotectors, anticancer, antidiabetic, anti-inflammatory, antiaging, antiviral, antiparasitic, and antimicrobial agents, among others. This review provides a basic overview of the chemical scaffolds present in mushrooms and their therapeutic implications in the human body.

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Section: Tremella Mesenterica (T Mesenterica)mentioning

confidence: 99%

Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications

Hassan,

Shahzadi,

Ransom

et al. 2023

IJMS

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“…Mannitol enhances the removal of toxic chemicals through the urine and protects against nephrotoxicity by preventing the concentration of harmful molecules in the tubular fluid . Mannitol, a glaucoma treatment, increases blood plasma osmolarity, which improves the passage of water from the eye into plasma and lowers intraocular pressure. , Mannitol is freely filtered by the glomeruli as a tool for determining renal function with less than 10% tubular reabsorption. Its urine excretion rate might therefore be used to calculate the glomerular filtration rate (GFR) …”

Section: Introductionmentioning

confidence: 99%

Exploring Diverse Amino Acid-Polyol Interactions Prevailing in Aqueous Systems at Different Temperatures by Physicochemical Contrivance Simultaneously Optimized by DFT

Roy,

Mondal,

Roy

et al. 2024

J. Chem. Eng. Data

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In this experimental study, we studied the molecular interactions of L-valine and L-leucine in separate aqueous solutions of D-mannitol at various temperatures and concentrations. The derived parameters, such as apparent molar volume (ϕ v ), limiting apparent molar volume (ϕ v 0 ), viscosity B-coefficient, and Gibbs free energies of activation per mole of solvent and solute, conductance, have been used to predict solute−solvent and solute−solute interactions based on the transition state theory and cosphere overlap model. By adjusting the concentration of L-valine and Lleucine, fluorescence spectra were measured, and the association constant was computed. Hydrophobic−hydrophobic interactions were seen in the 1 H NMR experiments, and these findings were supported by computational research. The primary goal of this research is to comprehend how biologically important D-mannitol interacts with significant amino acids in aqueous solutions, which could be suitable for the pharmaceutical sector. These results are anticipated to offer important foundational knowledge for comprehending how sugar alcohol affects protein conformational stability.

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“…While endotamponade purity and viscosity have progressed substantially over the years, there are nonetheless sure problems that could arise [1]. One takes a look at located that 2.2% to 56.0% of sufferers who had vitrectomy skilled extended IOP because of silicone oil tamponade [2][3]. Three in a take a look at performed via way of means of Montanari et al, It changed into proven that 18. five% of sufferers who had pars plana vitrectomy with silicon oil injection afterwards advanced secondary glaucoma; this changed into the outcome of trabecular meshwork blockage mediated via way of means of silicone oil emulsification.…”

Section: Introductionmentioning

confidence: 99%

Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized Silicon-Oil-Filled and Non Vitrectomized Eyes: A Prospective Comparative Study

Ahmad¹,

Nawaz²,

Ali³

et al. 2022

PJMHS

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Purpose: Our studies turned into designed to assess the consequences of intravenous mannitol on intraocular pressure (IOP) in vitrectomized silicon-oil-stuffed eyes and to assessment those consequences with the ones received in non-vitrectomized eyes. Study Design: Prospective comparative case study Place and Duration: Ophthalmology department, Peshawar Medical College and affiliated hospitals, Peshawar for the duration from 1st Jan, 2022 to 30th June, 2022. Materials and Methods: All eyes with intraocular pressure lower than 38 mm Hg were considered. Group 1 had their vitreous removed and filled with silicon oil to reduce IOP, whereas Group 2 had their vitreous removed and their eyes were left open (Group 2). Mannitol (20 percent solution, 1 g/kg) was infused over the course of 30 minutes, and intraocular pressure was measured every 30 minutes during the first 2 hours, then again at the 3rd, 4th, and 6th hours post-administration. Results: In all, 36 eyes from each group were used. Group 1 had a decrease in mean (SD) IOP from 46.4 4.0 to 41.5 6.8 at 30 minutes, 38.5 ± 7.2 at 60 proceedings, 35.1 ± 7.5 at 90 records, 33.4 ± 9.3 at 2 hours, 31.8 ±9.5 at 3 hours, 30.8 ±10 at 4 hours, and 30.7 ± 9.9 at 6 hours, whereas group 2 saw a decrease in mean (SD) IOP from 46.9 5.4 IOP dropped significantly from baseline in all groups at all-time points up to 4 hours (P0.001). While both groups saw a reduction in intraocular pressure (IOP) after 4 and 6 hours of mannitol administration, there was no significant difference between the groups. Conclusion: Mannitol has been shown to dramatically lower IOP in both vitrectomized eyes with silicon fillings and non-vitrectomized eyes. Keywords: Mannitol, Intraocular pressure, Silicon-oil-filled eye, Vitrectomy

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The use of mannitol in neurosurgery and neuro-ophthalmology

Cited by 5 publications

References 77 publications

Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications

Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications

Exploring Diverse Amino Acid-Polyol Interactions Prevailing in Aqueous Systems at Different Temperatures by Physicochemical Contrivance Simultaneously Optimized by DFT

Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized Silicon-Oil-Filled and Non Vitrectomized Eyes: A Prospective Comparative Study

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