The Use of Midodrin in the Treatment of Ejaculation Disorders following Retroperitoneal Lymphadenectomy

Partial Ejaculatory Incompetence: the Therapeutic Effect of Midodrine1, an Orally Active Selective Alpha-Adrenoceptor Agonist

“…Mi dodrine is a new alpha-adrenergic agonist that has a pro tracted onset of action and longer duration of activity than earlier alpha-adrenergic stimulants [Pittner et al, 1976;Paumgartner et al, 1970], Jonas et al [1979] reported the use of Midodrine in the treatment of loss of ejaculation after retroperitoneal lymphadenectomy. They reported improvement in orgasmic response and in erec tion after long-term oral treatment with the drug.…”

Diagnostic and treatment of retrograde ejaculation as a manifestation of urogenital form of autonomic diabetic polyneuropathy

“…Консервативная терапия РЭ может включать приме-нение антигистаминных препаратов (бромфенирамин), трициклических антидепрессантов (имипрамин) и других средств, в том числе антихолинергических и адренергиче-ских агентов [8][9][10][11]. Afara и El Tabie (2008) в своем иссле-довании получили данные относительно эффективности в отношении восстановления антеградной эякуля ции при применении имипрамина у 38% и эфедрина у 48% мужчин с РЭ вследствие СД, а также комбинации обоих препаратов в 61,5% случаев.…”

Key central pattern generators of the spinal cord

“…This drug or its shorter-acting version physostigmine, tested a few years later, is no longer utilized because of severe side effects, including autonomic dysreflexia and death (Guttmann, 1971;Jesionowska and Hemmings, 1991;Biering-Sorensen and Sonksen, 2001). Midodrine (an alpha-1 agonist) was also shown to induce either normal (anterograde, i.e., outside the urethral meatus) or abnormal (retrograde, i.e., back inside into the bladder) ejaculation in patients with SCI, but, as with cholinesterase inhibitors, it was also found to increase blood pressure and autonomic dysreflexia (Jonas et al, 1979;Riley and Riley, 1982;Staerman and al., 2001;Blanchard-Dauphin et al, 2005;Garcia-Bravo et al, 2006;Courtois et al, 2008).…”