The use of misoprostol for termination of early pregnancy

Second trimester abortion using intravaginal misoprostol

“…Similar to our result, several trials of repeated doses of 200 to 800 μg of vaginal misoprostol reported success rate of 20% to 60% [2,3]. Small variations in the success rate of different dosages dictate considering other outcome in medical judgments in dosage administrations.…”

Early termination of pregnancy by single-dose 800 μg misoprostol compared with surgical evacuation

“…Mean age (26 years) and parity (2) in both groups were the same. Mean gestational age in group I was 48 days and in group II was 47 days.…”

“…Studies show that compounds like antiprogesterones and prostaglandins can be safely used. The prostaglandin E 1 (PGE 1 ) analogue misoprostol can be administered by various routes with minimal side effects and has high efficacy rates (1)(2)(3)(4). A Cochrane review in 2004 (5) described misoprostol in a dose of 800 mg was more effective than any other prostaglandin.…”

Efectividad del tratamiento médico con misoprostol según dosis administrada en aborto retenido menor de 12 semanas

“…Neilson y cols (17), obtuvieron una tasa de expulsión utilizando dosis de 600 a 800 µg por vía vaginal de 70 a 90%. Estudios europeos alcanzaron cifras cercanas al 46% y 66% de abortos completos con dosis de 200 µg y 400 µg de misoprostol, respectivamente (18). Rabey cols (19), en la interrupción del embarazo entre las 9 y 12 semanas, con 2 dosis de 200 o 400 µg de misoprostol, obtuvieron aborto parcial/completo de 9 y 11% respectivamente.…”