The Use of Molecular Imaging to Evaluate Radiation Fields in the Adjuvant Setting of Breast Cancer

Bral, Samuel; Vinh-Hung, Vincent; Everaert, Hendrik; Coninck, P. De; Storme, Guy

doi:10.1007/s00066-008-1769-7

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…The procedure at the UZ Brussel has been previously reported [17]. The patients fasted for at least 6 h. Prescanning glucose levels were systematically checked.…”

Section: Fdg Pet Image Acquisition and Reconstructionmentioning

confidence: 99%

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Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Vinh-Hung

Everaert

Lamote

et al. 2012

Eur J Nucl Med Mol Imaging

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Purpose To explore the preoperative utility of FDG PET for the diagnosis and prognosis in a retrospective breast cancer case series. Methods In this retrospective study, 104 patients who had undergone a preoperative FDG PET scan for primary breast cancer at the UZ Brussel during the period 2002-2008 were identified. Selection criteria were: histological confirmation, FDG PET performed prior to therapy, and breast surgery integrated into the primary therapy plan. Patterns of increased metabolism were recorded according to the involved locations: breast, ipsilateral axillary region, internal mammary chain, or distant organs. The end-point for the survival analysis using Cox proportional hazards was disease-free survival.The contribution of prognostic factors was evaluated using the Akaike information criterion and the Nagelkerke index. Results PET positivity was associated with age, gender, tumour location, tumour size >2 cm, lymphovascular invasion, oestrogen and progesterone receptor status. Among 63 patients with a negative axillary PET status, 56 (88.9 %) had three or fewer involved nodes, whereas among 41 patients with a positive axillary PET status, 25 (61.0 %) had more than three positive nodes (P<0.0001). In the survival analysis of preoperative characteristics, PET axillary node positivity was the foremost statistically significant factor associated with decreased disease-free survival (hazard ratio 2.81, 95% CI 1.17-6.74). Conclusion Preoperative PET axillary node positivity identified patients with a higher burden of nodal involvement, Electronic supplementary material The online version of this article

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“…The procedure at the UZ Brussel has been previously reported [17]. The patients fasted for at least 6 h. Prescanning glucose levels were systematically checked.…”

Section: Fdg Pet Image Acquisition and Reconstructionmentioning

confidence: 99%

“…The rationale was to use the scan for staging, and to improve target delineation for subsequent postoperative radiation treatment [17]. In the present study, we evaluated the diagnostic utility of the preoperative PET scan with regard to lymph node involvement, and also evaluated its prognostic value with regard to survival.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Vinh-Hung

Everaert

Lamote

et al. 2012

Eur J Nucl Med Mol Imaging

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“…Increased mortality hazard observed in association with use of postmastectomy radiotherapy among patients with medial tumors and ≥ 4 ALN+ raises the concern that treatment-related toxicities, particularly with large radiotherapy volumes to encompass IMN, may be a contributing factor counterbalancing the beneficial effects of radiotherapy. Until results of modern trials are available, the possibility that routine radiotherapy of the IMN represents an overtreatment should be discussed and should be balanced against a more targeted approach [2,44,45], in which radiotherapy of the IMN would be limited to patients with IMN metastases [56].…”

Section: Groupmentioning

confidence: 99%

The Effect of Adjuvant Radiotherapy on Mortality Differs According to Primary Tumor Location in Women with Node-Positive Breast Cancer

et al. 2009

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Medial tumor location is a significant adverse prognostic factor that should be considered in treatment decision- making for women with ALN+ BC. Improved survival was observed with radiotherapy use in all subgroups, except in women with medial tumors with > or = 4 ALN+ treated with postmastectomy radiotherapy. These findings raise concern that the favorable effect of radiotherapy may be offset by excess toxicities in the latter subgroup.

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“…Currently, several studies investigated the value of [ 18 F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for staging and treatment planning in various malignancies [3,15,16,24,33]. Also in anal cancer, previous investigations showed that with FDG-PET more involved lymph nodes can be detected than with clinical examination or CT [5,22,28,30].…”

Section: Introductionmentioning

confidence: 99%