The use of noble metal coatings and nanoparticles for the modification of medical implant materials

Basova, Tamara V.; Vikulova, E. S.; Dorovskikh, S. I.; Hassan, Aseel; Morozova, N. B.

doi:10.1016/j.matdes.2021.109672

Cited by 95 publications

(42 citation statements)

References 198 publications

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“…Therefore, we showed the effect of toxicity of metal nanoparticles; however, the aspect of their possible diffusion into the cytoplasm of the cell needs further investigation. An alternative hypothesis that could explain the cytotoxic effect of AuNPs is an activity in generating ROS fragments that cause oxidative cell stress [ 2 ]. Most studies attribute the ability to generate ROS to ultradispersed Au particles (several nanometers).…”

Section: Resultsmentioning

confidence: 99%

“…The main properties that any of the implant materials should possess, first of all, reliability and safety of their use, including biocompatibility, osseointegration, and antibacterial properties [ 1 ]. Implants must be inert to living tissues, be not carcinogenic, have a sufficient margin of mechanical strength, and be resistant to the internal environment of the body [ 2 , 3 , 4 ]. Biocompatibility and prolonged antibacterial effect are of particular importance, where patients have reduced immunity and a tendency to infectious complications.…”

Section: Introductionmentioning

confidence: 99%

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Noble Metals for Modern Implant Materials: MOCVD of Film Structures and Cytotoxical, Antibacterial, and Histological Studies

et al. 2021

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This work is aimed at developing the modification of the surface of medical implants with film materials based on noble metals in order to improve their biological characteristics. Gas-phase transportation methods were proposed to obtain such materials. To determine the effect of the material of the bottom layer of heterometallic structures, Ir, Pt, and PtIr coatings with a thickness of 1.4–1.5 μm were deposited by metal–organic chemical vapor deposition (MOCVD) on Ti6Al4V alloy discs. Two types of antibacterial components, namely, gold nanoparticles (AuNPs) and discontinuous Ag coatings, were deposited on the surface of these coatings. AuNPs (11–14 nm) were deposited by a pulsed MOCVD method, while Ag films (35–40 nm in thickness) were obtained by physical vapor deposition (PVD). The cytotoxic (24 h and 48 h, toward peripheral blood mononuclear cells (PBMCs)) and antibacterial (24 h) properties of monophase (Ag, Ir, Pt, and PtIr) and heterophase (Ag/Pt, Ag/Ir, Ag/PtIr, Au/Pt, Au/Ir, and Au/PtIr) film materials deposited on Ti-alloy samples were studied in vitro and compared with those of uncoated Ti-alloy samples. Studies of the cytokine production by PBMCs in response to incubation of the samples for 24 and 48 h and histological studies at 1 and 3 months after subcutaneous implantation in rats were also performed. Despite the comparable thickness of the fibrous capsule after 3 months, a faster completion of the active phase of encapsulation was observed for the coated implants compared to the Ti alloy analogs. For the Ag-containing samples, growth inhibition of S. epidermidis, S. aureus, Str. pyogenes, P. aeruginosa, and Ent. faecium was observed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noble Metals for Modern Implant Materials: MOCVD of Film Structures and Cytotoxical, Antibacterial, and Histological Studies

et al. 2021

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“…A thorough summary of the microstructures and antimicrobial properties of Ag/Cu combinations was presented by Fan et al [ 41 ]. On the other hand, from the electrochemical point of view, the contact of two metals creates a galvanic pair that facilitates the oxidation of the more active component [ 45 ]. The reason for the higher activity of Ag/Cu and Au/Cu was that they work as galvanic couples.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Antibacterial Metal Surfaces Using Magnetron-Sputtering Method

et al. 2021

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One-hundred-nanometer films consisting of silver, copper, and gold nanocrystallites were prepared, and their antibacterial properties were quantitatively measured. The magnetron-sputtering method was used for the preparation of the metallic films over the glass plate. Single- and double-layer films were manufactured. The films were thoroughly characterized with the XRD, SEM, EDS, and XPS methods. The antibacterial activity of the samples was investigated. Gram-negative Escherichia coli, strain K12 ATCC 25922 (E. coli), and Gram-positive Staphylococcus epidermidis, ATCC 49461 (S. epidermidis), were used in the microbial tests. The crystallite size was about 30 nm in the cases of silver and gold and a few nanometers in the case of copper. Significant oxidation of the copper films was proven. The antibacterial efficacy of the tested samples followed the order: Ag/Cu > Au/Cu > Cu. It was concluded that such metallic surfaces may be applied as contact-killing materials for a more effective fight against bacteria and viruses.

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“…The development of implants with both high strength and biosafety has long been a hotspot in the field of biomedical engineering [ 1 – 3 ]. Due to their excellent corrosion resistance, superior mechanical properties and biocompatibility, titanium (Ti) implants have been widely used in orthopedic surgery, oral implantation, and other medical devices [ 4 – 6 ]. However, two major issues have arisen in their clinical application: implant-related infection and poor osteogenesis [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

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Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

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The use of noble metal coatings and nanoparticles for the modification of medical implant materials

Cited by 95 publications

References 198 publications

Noble Metals for Modern Implant Materials: MOCVD of Film Structures and Cytotoxical, Antibacterial, and Histological Studies

Noble Metals for Modern Implant Materials: MOCVD of Film Structures and Cytotoxical, Antibacterial, and Histological Studies

Fabrication of Antibacterial Metal Surfaces Using Magnetron-Sputtering Method

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

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