The Use of Photodynamic Therapy for Skin Cancer

Karrer, Sigrid; Szeimies, Rolf‐Markus; Abels, Christoph; Landthaler, Míchael

doi:10.1159/000026783

Cited by 11 publications

(4 citation statements)

References 40 publications

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“…These photosensitized conjugates may also potentially be used as agents for photodynamic therapy (PDT) of superficial cancers such as skin cancer. 26 The hydrophilic nature of the QD conjugates makes them ideal for uptake into inflamed tissues, often a barrier to successful PDT. 27 …”

Section: Discussionmentioning

confidence: 99%

Photosensitization of CdSe/ZnS QDs and reliability of assays for reactive oxygen species production

2010

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CdSe/ZnS quantum dots (QDs) conjugated to biomolecules that can act as electron donors are said to be "photosensitized": that is, they are able to oxidize or reduce molecules whose redox potential lies inside their band edges, in particular molecular oxygen and water. This leads to the formation of reactive oxygen species (ROS) and phototoxicity. In this work, we quantify the generation of different forms of ROS from as-synthesized QDs in toluene; water-solubilized, unconjugated QDs; QDs conjugated to the neurotransmitter dopamine; and dopamine alone. Results of indirect fluorescent ROS assays, both in solution and inside cells, are compared with those of spin-trap electron paramagnetic resonance spectroscopy (EPR). The effect of these particles on the metabolism of mammalian cells is shown to be dependent upon light exposure and proportional to the amount of ROS generated.

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Section: Discussionmentioning

confidence: 99%

Photosensitization of CdSe/ZnS QDs and reliability of assays for reactive oxygen species production

2010

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“…The substances most frequently used for PDT of skin diseases are 5-aminolaevulinic acid (ALA) and its ester, methyl aminolaevulinate (MAL). Several studies have so far proven the effectiveness of topical ALA-⁄ MAL-PDT in the treatment of AK and other superficial skin tumors (2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self‐adhesive 5‐aminolaevulinic acid patch

Hauschild

Popp²,

Stockfleth

et al. 2009

Experimental Dermatology

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“…The technique is based on the preferential accumulation of porphyrin in tumor tissue with subsequent cytotoxicity mediated by singlet oxygen production (1). Its therapeutic usefulness is due to selective and rapid tumor necrosis after illumination of the porphyrin-containing tumor with visible light (2).…”

Section: Introductionmentioning

confidence: 99%

“…Its therapeutic usefulness is due to selective and rapid tumor necrosis after illumination of the porphyrin-containing tumor with visible light (2). Tumor necrosis seems to be preceded by significant alterations in the vascular system of the tumor (1,2). Hematoporphyrin derivative (HpD), first developed by Lipson in 1960, and a purified fraction, dihematoporphyrin ether, known as Photofrin II ® , are complex mixtures used for tumor localization and treatment (3).…”

Section: Introductionmentioning

confidence: 99%

The effect of porphyrins on normal and transformed mouse cell lines in the presence of visible light

Tita

Perussi

2001

Braz J Med Biol Res

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Photodynamic therapy consists of the uptake of a photosensitizing dye, often a porphyrin, by tumor tissue and subsequent irradiation of the tumor with visible light of an appropriate wavelength matched to the absorption spectrum of the photosensitizing dye. This class of molecules produces reactive oxygen species when activated by light, resulting in a direct or indirect cytotoxic effect on the target cells. Photodynamic therapy has been used in the treatment of cancer but the technology has a potential for the treatment of several disease conditions mainly because of its selectivity. However, it is not clear why the porphyrins are retained preferentially by abnormal tissue. This paper describes a study of the effect of the association of porphyrin and visible light on two mouse fibroblast cell lines: A31, normal cells and B61, an EJ-ras transformed variant of A31. Two water-soluble porphyrins were used, a positively charged one, tetra(N-methyl-4-pyridyl)porphyrin chloride, and a negatively charged one, tetra(4-sulfonatophenyl)porphyrin-Na salt (TPPS 4 ) in order to assess the effect on cell survival. The results suggest that the B61 cell line is more sensitive to incubation with the anionic porphyrin (TPPS 4 ) followed by light irradiation and that the anionic porphyrin is more efficient in killing the cells than the cationic porphyrin.

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The Use of Photodynamic Therapy for Skin Cancer

Cited by 11 publications

References 40 publications

Photosensitization of CdSe/ZnS QDs and reliability of assays for reactive oxygen species production

Photosensitization of CdSe/ZnS QDs and reliability of assays for reactive oxygen species production

Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self‐adhesive 5‐aminolaevulinic acid patch

The effect of porphyrins on normal and transformed mouse cell lines in the presence of visible light

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