The Use of Prindolol (Visken) in the Treatment of Hypertension

Morgan, T. O.; Wj, Louis; Jk, Dawborn; Ae, Doyle

doi:10.5694/j.1326-5377.1972.tb47306.x

Cited by 64 publications

(15 citation statements)

References 9 publications

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“…BETA adrenergic blocking drugs are a significant advance in the control of hypertension. If used in large doses in combination with a thiazide diuretic they produce a fall in blood pressure and a degree of blood pressure control that compares favourably with other first line antihypertensive drugs (Prichard and Giltam, 1969;Morgan et al, 1972;Zacharias and Cowen, 1970). A large number of beta adrenergic blocking drugs now exist.…”

Section: Discussionmentioning

confidence: 99%

“…However, the ratio of the dosage needed to produce an antihypertensive effect was similar to the relative beta adrenergic blocking potency of the four drugs. While the falls in blood pressure may be in part due to depression of cardiac output, the high incidence of central nervous system side effects and the relative lack of postural hypotension with these drugs suggest that an action on central vasometer centres may also be important (Morgan et al, 1972). If these drugs do indeed reduce blood pressure by an action at a central site, then the variation in dose required for different drugs may reflect the ease with which these substances enter the brain.…”

Section: Discussionmentioning

confidence: 99%

“…The beta adrenergic blocking drugs were added to the previous therapeutic regime and when possible other drugs were ceased. Full details of the method used have been reported previously (Morgan et al, 1972). The response of the patients was graded as follows.…”

Section: Methodsmentioning

confidence: 99%

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A comparison of beta adrenergic blocking drugs in the treatment of hypertension

Morgan

Anavekar

Sabto

et al. 1974

Postgraduate Medical Journal

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SummaryBeta adrenergic blocking drugs were found to be effective hypotensive agents in the long-term treatment of patients with hypertension. In 40 % of patients they appeared to be an extremely satisfactory antihypertensive agent. The fall in blood pressure was confirmed in a double blind study which also indicated that propranolol, prindolol, alprenolol and MK 950 (timolol) had similar antihypertensive properties. Propranolol and timolol reduced the pulse rate more than prindolol and alprenolol but the fall in blood pressure induced by the four drugs was not significantly different.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A comparison of beta adrenergic blocking drugs in the treatment of hypertension

Morgan

Anavekar

Sabto

et al. 1974

Postgraduate Medical Journal

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“…There have been no controlled trials comparing the effects of different agents on sleep in similar b-receptor blocking or therapeutic doses, but there is some evidence that pindolol is particularly liable to produce insomnia and abnormal dreaming. (12,13) and it is of interest that this drug produces the highest CSF/plasma ratio of the b-blockers that we have studied (14).…”

Section: Central Action Of β β-Adrenoceptor Blocking Drugsmentioning

confidence: 99%

β-Adrenoceptor Blockade and Migraine

1982

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Except for propranolol, no other Beta-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs in unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. Beta-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.

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“…8-Adrenergic-blocking drugs reduce both blood pressure (Prichard & Gillam, 1969;Morgan, Louis, Dawborn & Doyle, 1972) and plasma renin activity (Stokes, Weber & Thonell, 1974;Buhler, Laragh, Baer, Vaughan & Brunner, 1972). It has been postulated that their action on the renin-angiotensin system may explain their hypotensive effect.…”

Section: Introductionmentioning

confidence: 99%

Changes in Plasma Renin Activity and Blood Pressure after Acute and Chronic Administration of β-Adrenergic Receptor-Blocking Drugs

1974

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1.Prindolol and propranolol chronically cause a fall in mean blood pressure and mean plasma renin activity, but no correlation was observed between the two variables.2. The response of blood pressure to prindolol and propranolol was not predicted by the basal plasma renin activity.3. Propranolol administered acutely caused the plasma renin activity to fall with no acute change in blood pressure, whereas prindolol caused the blood pressure to fall with no change in plasma renin activity.4. The effects of 8-adrenergic-blocking drugs on plasma renin activity and blood pressure can be dissociated and it is unlikely that their hypotensive action is mediated through the renin-angiotensin system. 5. Basal plasma renin activity does not identify the patients who will respond to P-adrenergic-blocking drugs.

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The Use of Prindolol (Visken) in the Treatment of Hypertension

Cited by 64 publications

References 9 publications

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

β-Adrenoceptor Blockade and Migraine

Changes in Plasma Renin Activity and Blood Pressure after Acute and Chronic Administration of β-Adrenergic Receptor-Blocking Drugs

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